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NCT06824402 · ClinicalTrials.gov registry record · NA
Cryoprobe Biopsy and Chronic Rejection in Lung Transplant Recipients
A NA study of Lung Transplant Rejection, sponsored by Mayo Clinic.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT06824402: Recruiting NA study of Lung Transplant Rejection, sponsored by Mayo Clinic.
NCT06824402 is a NA study of Lung Transplant Rejection that is actively recruiting participants, run by Mayo Clinic. The registered enrollment target is 100 participants, below the 644-participant average among 6 other Lung Transplant Rejection trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06824402, a NA study of Lung Transplant Rejection, is actively recruiting participants, sponsored by Mayo Clinic.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to evaluate which biopsy collection method helps to better diagnose rejection and relevant pathologic findings in lung transplant recipients. The main questions it aims to answer are: Does the 1.1 mm cryoprobe or the biopsy forceps provide better quality samples of lung tissue for detecting rejection in transplant recipients? How much tissue is adequate for lung transplant 1.1 mm cryobiopsy samples as compared to biopsy forceps? Which samples received by the pathologist did they find they were most confident to exclude rejection, based on their satisfaction with the samples? Which collection method has the least amount of procedural time? Researchers will compare lung tissue samples obtained using a 1.1mm cryoprobe and a biopsy forceps during the lung transplant. Participants will: Be randomly assigned to receive either the cryoprobe or biopsy forceps collection method at the time of biopsy. Assessed for any adverse events following the biopsy for up to 30 days after transplant.
Primary Outcome
Histological accessibility grade is determined by the pathologist according to the Lung Allograft Standard Histological Analysis (LASHA) scale and the 2007 Revision of the 1996 working formulation for the Standardization of Nomenclature in the Diagnosis of Lung Rejection, published by the ISHLT.
Conditions Studied
Interventions
- DEVICE Forceps Biopsy
- DEVICE Cryoprobe Biopsy
Study Locations (1)
Minnesota
- Mayo Clinic in Rochester - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-02-17 |
| Est. Completion | 2027-09-30 |
| Phase | NA |
What NCT06824402 shows while recruiting
NCT06824402 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 644-participant average among 6 other Lung Transplant Rejection trials with a reported enrollment target (84% lower).
The record links to 1 condition, with Lung Transplant Rejection appearing as the primary indexed condition, and to 2 interventions - of which Forceps Biopsy is the first listed.
NCT06824402 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT06824402 about?
NCT06824402 is a clinical study titled "Cryoprobe Biopsy and Chronic Rejection in Lung Transplant Recipients". The goal of this clinical trial is to evaluate which biopsy collection method helps to better diagnose rejection and relevant pathologic findings in lung transplant recipients. The main questions it aims to answer are: Does the 1.1 mm cryoprobe or the biopsy forceps provide better quality samples o...
What is the current status of trial NCT06824402?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2025-02-17. Estimated completion is 2027-09-30.
What conditions does trial NCT06824402 study?
This clinical trial studies the following conditions: Lung Transplant Rejection.
What interventions are being tested in trial NCT06824402?
The interventions under investigation include: Forceps Biopsy (DEVICE), Cryoprobe Biopsy (DEVICE).
Who is sponsoring clinical trial NCT06824402?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06824402 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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