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RECRUITING Phase 2

Optimizing GVHD Prophylaxis After Allogeneic Hematopoietic Cell Transplantation

NCT06799195 · View on ClinicalTrials.gov ↗

Study Summary

This study will compare post-transplant health-related quality of life following the use of standard versus attenuated dose of post-transplant cyclophosphamide in addition to two-drug graft-versus-host disease (GVHD) prophylaxis among recipients of allogeneic hematopoietic stem cell transplant.

Interventions

  • DRUG Sirolimus
  • DRUG Attenuated-dose Cyclophosphamide
  • DRUG High-dose Cyclophosphamide
  • DRUG Mycophenolate Mofetil (MMF)

Study Locations (1)

Nebraska

  • University of Nebraska Medical Center — Omaha

Trial Details

FieldValue
Enrollment Target 126 participants
Start Date 2025-06-23
Est. Completion 2031-11
Phase Phase 2

Sponsor

University of Nebraska

272 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06799195

The ClinicalTrials.gov registry entry for NCT06799195 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 126 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Nebraska, which has 272 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Hematological Malignancies appearing as the primary indexed condition, and to 4 interventions — of which Sirolimus is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06799195 reports 1 study location spanning 1 distinct geographic area — top geographies include Nebraska. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06799195 about?

NCT06799195 is a clinical study titled "Optimizing GVHD Prophylaxis After Allogeneic Hematopoietic Cell Transplantation". This study will compare post-transplant health-related quality of life following the use of standard versus attenuated dose of post-transplant cyclophosphamide in addition to two-drug graft-versus-host disease (GVHD) prophylaxis among recipients of allogeneic hematopoietic stem cell transplant.

What is the current status of trial NCT06799195?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 126 participants. The study started on 2025-06-23. Estimated completion is 2031-11.

What conditions does trial NCT06799195 study?

This clinical trial studies the following conditions: Hematological Malignancies, Graft-versus-Host Disease (GVHD). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06799195?

The interventions under investigation include: Sirolimus (DRUG), Attenuated-dose Cyclophosphamide (DRUG), High-dose Cyclophosphamide (DRUG), Mycophenolate Mofetil (MMF) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06799195?

This trial is sponsored by University of Nebraska, which has 272 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06799195 being conducted?

This trial has 1 study location across Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial