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COMPLETED Phase 2

A Study of Pembrolizumab/Vibostolimab (MK-7684A) in Relapsed/Refractory Hematological Malignancies (MK-7684A-004, KEYVIBE-004)

NCT05005442 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of the study is to determine the safety and tolerability of pembrolizumab/vibostolimab (MK-7684A) in hematological malignancies. This study will also evaluate the overall response rate (ORR), the duration of response (DOR), and disease control rate (DCR) following administration of pembrolizumab/vibostolimab. In addition, this study will characterize pharmacokinetic (PK) profile of vibostolimab (MK-7684).

Conditions Studied

Interventions

  • BIOLOGICAL Pembrolizumab/vibostolimab coformulation

Study Locations (20)

New Jersey

  • John Theurer Cancer Center at Hackensack University Medical Center ( Site 0004) — Hackensack
  • Rutgers Cancer Institute of New Jersey ( Site 0023) — New Brunswick

Quebec

  • Jewish General Hospital ( Site 0032) — Montreal
  • McGill University Health Centre ( Site 0037) — Montreal

Region M. de Santiago

  • Instituto Nacional del Cancer ( Site 0626) — Chile
  • FALP-UIDO ( Site 0623) — Santiago

California

  • City of Hope Comprehensive Cancer Center-Hematology ( Site 0024) — Duarte

Colorado

  • University of Colorado Anschutz Medical Campus-The Center for Cancer and Blood Disorders ( Site 0021 — Aurora

Illinois

  • University of Chicago Medical Center ( Site 0005) — Chicago

Michigan

  • Henry Ford Hospital ( Site 0003) — Detroit

Texas

  • University of Texas MD Anderson Cancer Center ( Site 0014) — Houston

Trial Details

FieldValue
Enrollment Target 192 participants
Start Date 2021-09-28
Est. Completion 2024-12-10
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05005442

The ClinicalTrials.gov registry entry for NCT05005442 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 192 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hematological Malignancies appearing as the primary indexed condition, and to 1 intervention — of which Pembrolizumab/vibostolimab coformulation is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05005442 reports 20 study locations spanning 17 distinct geographic areas — top geographies include New Jersey, Quebec, Region M. de Santiago. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05005442 about?

NCT05005442 is a clinical study titled "A Study of Pembrolizumab/Vibostolimab (MK-7684A) in Relapsed/Refractory Hematological Malignancies (MK-7684A-004, KEYVIBE-004)". The purpose of the study is to determine the safety and tolerability of pembrolizumab/vibostolimab (MK-7684A) in hematological malignancies. This study will also evaluate the overall response rate (ORR), the duration of response (DOR), and disease control rate (DCR) following administration of pembr...

What is the current status of trial NCT05005442?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 192 participants. The study started on 2021-09-28. Estimated completion is 2024-12-10.

What conditions does trial NCT05005442 study?

This clinical trial studies the following conditions: Hematological Malignancies. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05005442?

The interventions under investigation include: Pembrolizumab/vibostolimab coformulation (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05005442?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05005442 being conducted?

This trial has 20 study locations across California, Colorado, Illinois, Michigan, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial