Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of Pembrolizumab/Vibostolimab (MK-7684A) in Relapsed/Refractory Hematological Malignancies (MK-7684A-004, KEYVIBE-004)
NCT05005442 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of the study is to determine the safety and tolerability of pembrolizumab/vibostolimab (MK-7684A) in hematological malignancies. This study will also evaluate the overall response rate (ORR), the duration of response (DOR), and disease control rate (DCR) following administration of pembrolizumab/vibostolimab. In addition, this study will characterize pharmacokinetic (PK) profile of vibostolimab (MK-7684).
Conditions Studied
Interventions
- BIOLOGICAL Pembrolizumab/vibostolimab coformulation
Study Locations (20)
New Jersey
- John Theurer Cancer Center at Hackensack University Medical Center ( Site 0004) — Hackensack
- Rutgers Cancer Institute of New Jersey ( Site 0023) — New Brunswick
Quebec
- Jewish General Hospital ( Site 0032) — Montreal
- McGill University Health Centre ( Site 0037) — Montreal
Region M. de Santiago
- Instituto Nacional del Cancer ( Site 0626) — Chile
- FALP-UIDO ( Site 0623) — Santiago
California
- City of Hope Comprehensive Cancer Center-Hematology ( Site 0024) — Duarte
Colorado
- University of Colorado Anschutz Medical Campus-The Center for Cancer and Blood Disorders ( Site 0021 — Aurora
Illinois
- University of Chicago Medical Center ( Site 0005) — Chicago
Michigan
- Henry Ford Hospital ( Site 0003) — Detroit
Texas
- University of Texas MD Anderson Cancer Center ( Site 0014) — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 192 participants |
| Start Date | 2021-09-28 |
| Est. Completion | 2024-12-10 |
| Phase | Phase 2 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05005442
The ClinicalTrials.gov registry entry for NCT05005442 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 192 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Hematological Malignancies appearing as the primary indexed condition, and to 1 intervention — of which Pembrolizumab/vibostolimab coformulation is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05005442 reports 20 study locations spanning 17 distinct geographic areas — top geographies include New Jersey, Quebec, Region M. de Santiago. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05005442 about?
NCT05005442 is a clinical study titled "A Study of Pembrolizumab/Vibostolimab (MK-7684A) in Relapsed/Refractory Hematological Malignancies (MK-7684A-004, KEYVIBE-004)". The purpose of the study is to determine the safety and tolerability of pembrolizumab/vibostolimab (MK-7684A) in hematological malignancies. This study will also evaluate the overall response rate (ORR), the duration of response (DOR), and disease control rate (DCR) following administration of pembr...
What is the current status of trial NCT05005442?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 192 participants. The study started on 2021-09-28. Estimated completion is 2024-12-10.
What conditions does trial NCT05005442 study?
This clinical trial studies the following conditions: Hematological Malignancies. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05005442?
The interventions under investigation include: Pembrolizumab/vibostolimab coformulation (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05005442?
This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05005442 being conducted?
This trial has 20 study locations across California, Colorado, Illinois, Michigan, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.