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NCT06793696 · ClinicalTrials.gov registry record · NA
Adaptive Decision Support for Addiction Treatment (ADAPT) Factorial Trial
A NA study, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 1,129
- Enrollment target
NCT06793696: Completed NA study, sponsored by Yale University.
NCT06793696 is a NA study that has completed, run by Yale University. The registered enrollment target is 1,129 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (20% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06793696, a NA study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 1,129 participants
- Enrollment target
Study Summary
This study is stage 1 of a larger study which refines and optimizes the EMBED\* clinical decision support (CDS; see NCT03658642) to increase number of ED physicians following standard of care for the administration of buprenorphine to appropriate patients with opioid use disorder. This study does not have open enrollment. Investigators will use a Multiphase Optimization STrategy (MOST) framework study with preparation, optimization, and confirmatory phases. In the current project, optimization phase, stage1 investigators will conduct a 2x2x2 factorial trial in which they expand EMBED to include sustainable implementation strategies: nurse prompt for withdrawal assessment, and targeted clinician prompt to use the CDS along with patient resources to promote equity and motivate readiness to start treatment. Later study phases will include optimization phase, stage 2: rapid-cycle randomized testing, and evaluation phase: a randomized trial of the optimized package compared to the original EMBED and the evaluation phase in which investigators will compare the efficacy of the optimized, multicomponent CDS package to the original EMBED CDS on ED-initiation of buprenorphine rates in patients with OUD in a randomized trial. \*EMBED is a user centered, clinician facing clinical decision support system integrated into the electronic health record workflow to facilitate initiating buprenorphine in the emergency department by: diagnosing opioid use disorder with a checklist based on the diagnostic criteria of the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, fifth edition), assessing the severity of withdrawal with the Clinical Opioid Withdrawal Scale (COWS), motivating patients to accept treatment with a scripted brief negotiation interview, and automating the electronic health record workflow, including clinical and after visit documentation, order entry, prescribing, and referral for ongoing treatment in the community
Primary Outcome
Proportion of eligible encounters with buprenorphine administered in the Emergency Department (ED) and/or prescribed buprenorphine on discharge from the ED. Obtained from EHR data.
Interventions
- OTHER Patient facing materials
- OTHER Nurse prompt
- OTHER Provider prompt
- OTHER EMBED
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,129 participants |
| Start Date | 2025-03-21 |
| Est. Completion | 2025-10-14 |
| Phase | NA |
What the finished NCT06793696 record still lists
NCT06793696 is an interventional study that assigns participants to a tested intervention. Its 1,129 participants enrollment target places it among the larger protocols in the corpus, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (20% lower).
The record links to 0 conditions, and to 4 interventions - of which Patient facing materials is the first listed.
NCT06793696 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06793696 about?
NCT06793696 is a clinical study titled "Adaptive Decision Support for Addiction Treatment (ADAPT) Factorial Trial". This study is stage 1 of a larger study which refines and optimizes the EMBED\* clinical decision support (CDS; see NCT03658642) to increase number of ED physicians following standard of care for the administration of buprenorphine to appropriate patients with opioid use disorder. This study does n...
What is the current status of trial NCT06793696?
This trial is currently completed. It is a NA study. The enrollment target is 1,129 participants. The study started on 2025-03-21. Estimated completion is 2025-10-14.
What interventions are being tested in trial NCT06793696?
The interventions under investigation include: Patient facing materials (OTHER), Nurse prompt (OTHER), Provider prompt (OTHER), EMBED (OTHER).
Who is sponsoring clinical trial NCT06793696?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06793696's enrollment target sits among peer trials
1,129 93rd of 2000 higher than 1,908 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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