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NCT06791837 · ClinicalTrials.gov registry record
Brain Blood Flow and Lactate in Non-obese and Obese Subjects
A clinical trial of Obesity and Diabetes, sponsored by University of Missouri-Columbia.
- Recruiting
- Registry status
- 24
- Enrollment target
- 1
- Study location
NCT06791837 is a study of Obesity and Diabetes that is actively recruiting participants, run by University of Missouri-Columbia. The registered enrollment target is 24 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06791837, a study of Obesity and Diabetes, is actively recruiting participants, sponsored by University of Missouri-Columbia.
- RECRUITING
- Registry status
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
Cerebral blood flow (CBF) is essential for maintaining brain health and function, as it ensures delivery oxygen and nutrients necessary to support neuronal activity. Reduced CBF can impair the brain's ability to meet its metabolic demands, leading to deficits in cognitive ability. Impairments in CBF are associated with cognitive decline and neurodegenerative disease such as Alzheimer's and dementia. Many factors influence CBF, but recently lactate has emerged as a key player. Blood glucose has long been considered the primary fuel for the brain, but emerging evidence indicates that lactate may be the preferred fuel for neurons, and lactate may become even more important under stressful conditions. Individuals with obesity often have impaired lactate metabolism resulting in higher resting blood lactate concentrations and reduced ability to clear lactate after a physiological stress. At the same time, it is known that exercise is a powerful intervention for improving lactate metabolism. Thus, this project seeks to investigate the role of lactate in brain blood flow in individuals with and without obesity as well as establish if short term exercise training (individuals with obesity only) will alter circulating lactate concentrations at rest and in response to exercise.
Interventions
- BEHAVIORAL EXERCISE
Study Locations (1)
Missouri
- University of Missouri - Columbia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2025-05-01 |
| Est. Completion | 2027-03-01 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06791837
The ClinicalTrials.gov registry entry for NCT06791837 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (97% lower). The listed sponsor is University of Missouri-Columbia, which has 291 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 1 intervention - of which EXERCISE is the first listed.
NCT06791837 reports 1 study location spanning 1 distinct geographic area - top geographies include Missouri.
Frequently Asked Questions
What is clinical trial NCT06791837 about?
NCT06791837 is a clinical study titled "Brain Blood Flow and Lactate in Non-obese and Obese Subjects". Cerebral blood flow (CBF) is essential for maintaining brain health and function, as it ensures delivery oxygen and nutrients necessary to support neuronal activity. Reduced CBF can impair the brain's ability to meet its metabolic demands, leading to deficits in cognitive ability. Impairments in CBF...
What is the current status of trial NCT06791837?
This trial is currently recruiting. The enrollment target is 24 participants. The study started on 2025-05-01. Estimated completion is 2027-03-01.
What conditions does trial NCT06791837 study?
This clinical trial studies the following conditions: Obesity, Diabetes.
What interventions are being tested in trial NCT06791837?
The interventions under investigation include: EXERCISE (BEHAVIORAL).
Who is sponsoring clinical trial NCT06791837?
This trial is sponsored by University of Missouri-Columbia, which has 291 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06791837 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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