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ACTIVE NOT RECRUITING Phase 2

A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma

NCT06748053 · View on ClinicalTrials.gov ↗

Study Summary

This study is trying to find the right dose of a long-lasting medicine called GSK5784283 for people with asthma that remains uncontrolled even though they are using regular asthma treatments. GSK5784283 blocks the action of an inflammatory protein called TSLP that may be contributing to your asthma. The study will be conducted in two parts - Part A (dose finding phase) and Part B (extended dosing phase). Part A will assess the lung function, asthma control, participant safety and certain markers of asthma inflammation in the air you breath out and in your blood. Part B will assess the safety and long-term effects of the repeated or single doses of GSK5784283.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG GSK5784283

Study Locations (20)

Florida

  • GSK Investigational Site — Aventura
  • GSK Investigational Site — Hialeah
  • GSK Investigational Site — Lake Worth
  • GSK Investigational Site — Leesburg
  • GSK Investigational Site — Miami
  • GSK Investigational Site — Miami
  • GSK Investigational Site — Miami
  • GSK Investigational Site — Miami
  • GSK Investigational Site — Plantation

California

  • GSK Investigational Site — Long Beach
  • GSK Investigational Site — Los Angeles
  • GSK Investigational Site — Redding
  • GSK Investigational Site — Riverside
  • GSK Investigational Site — Sacramento
  • GSK Investigational Site — San Jose

Colorado

  • GSK Investigational Site — Colorado Springs
  • GSK Investigational Site — Lakewood
  • GSK Investigational Site — Wheat Ridge

Arkansas

  • GSK Investigational Site — Little Rock

Connecticut

  • GSK Investigational Site — New Haven

Trial Details

FieldValue
Enrollment Target 307 participants
Start Date 2025-02-10
Est. Completion 2027-09-09
Phase Phase 2

Sponsor

GlaxoSmithKline

558 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06748053

The ClinicalTrials.gov registry entry for NCT06748053 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 307 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GlaxoSmithKline, which has 558 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Asthma appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06748053 reports 20 study locations spanning 5 distinct geographic areas — top geographies include Florida, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06748053 about?

NCT06748053 is a clinical study titled "A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma". This study is trying to find the right dose of a long-lasting medicine called GSK5784283 for people with asthma that remains uncontrolled even though they are using regular asthma treatments. GSK5784283 blocks the action of an inflammatory protein called TSLP that may be contributing to your asthma....

What is the current status of trial NCT06748053?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 307 participants. The study started on 2025-02-10. Estimated completion is 2027-09-09.

What conditions does trial NCT06748053 study?

This clinical trial studies the following conditions: Asthma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06748053?

The interventions under investigation include: Placebo (DRUG), GSK5784283 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06748053?

This trial is sponsored by GlaxoSmithKline, which has 558 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06748053 being conducted?

This trial has 20 study locations across Arkansas, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial