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RECRUITING Phase 1

A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas

NCT06090539 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma.

Interventions

  • DRUG Mosunetuzumab
  • DRUG Rituximab
  • DRUG BMS-986458
  • DRUG Glofitamab/Obinutuzumab

Study Locations (20)

Other

  • CHU SAINT ELOI - Departement Hematologie Clinique — Montpellier
  • Hôpital Saint-Louis — Paris
  • Institut Claudius Regaud — Toulouse

Florida

  • Local Institution - 0068 — Jacksonville
  • Local Institution - 0027 — Tampa

New York

  • Local Institution - 0047 — Lake Success
  • Memorial Sloan Kettering Cancer Center — New York

Arizona

  • Mayo Clinic in Arizona - Phoenix — Phoenix

California

  • City of Hope Comprehensive Cancer Center — Duarte

Kansas

  • Local Institution - 0014 — Fairway

Massachusetts

  • Dana-Farber Cancer Institute — Boston

Minnesota

  • Mayo Clinic in Rochester, Minnesota — Rochester

Trial Details

FieldValue
Enrollment Target 308 participants
Start Date 2023-12-29
Est. Completion 2028-10-28
Phase Phase 1

Sponsor

Bristol-Myers Squibb

504 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06090539

The ClinicalTrials.gov registry entry for NCT06090539 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 308 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bristol-Myers Squibb, which has 504 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Relapsed/Refractory Non-Hodgkin Lymphoma appearing as the primary indexed condition, and to 4 interventions — of which Mosunetuzumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06090539 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Other, Florida, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06090539 about?

NCT06090539 is a clinical study titled "A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas". The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in pa...

What is the current status of trial NCT06090539?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 308 participants. The study started on 2023-12-29. Estimated completion is 2028-10-28.

What conditions does trial NCT06090539 study?

This clinical trial studies the following conditions: Relapsed/Refractory Non-Hodgkin Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06090539?

The interventions under investigation include: Mosunetuzumab (DRUG), Rituximab (DRUG), BMS-986458 (DRUG), Glofitamab/Obinutuzumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06090539?

This trial is sponsored by Bristol-Myers Squibb, which has 504 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06090539 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Kansas, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial