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RECRUITING Phase 2

Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis

NCT06747858 · View on ClinicalTrials.gov ↗

Study Summary

ARCT-032-02 is a Phase 2, open-label, multicenter, multiple-ascending dose study of ARCT-032 in adults with CF who are not eligible for CFTR modulator therapy or are not taking CFTR modulators due to drug intolerance, poor response, or lack of access to modulators.

Interventions

  • BIOLOGICAL ARCT-032

Study Locations (11)

Florida

  • Joe DiMaggio Children's Hospital — Hollywood
  • Central Florida Pulmonary Group — Orlando

Arizona

  • University of Arizona — Tucson

Arkansas

  • University of Arkansas for Medical Sciences — Little Rock

California

  • Children's Hospital of Los Angeles — Los Angeles

Illinois

  • The Cystic Fibrosis Institute — Northfield

Massachusetts

  • Boston Children's Hospital — Boston

Missouri

  • Washington University — St Louis

Tennessee

  • Vanderbilt University — Nashville

Trial Details

FieldValue
Enrollment Target 12 participants
Start Date 2024-12-12
Est. Completion 2025-12
Phase Phase 2

Sponsor

Arcturus Therapeutics

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06747858

The ClinicalTrials.gov registry entry for NCT06747858 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Arcturus Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Cystic Fibrosis appearing as the primary indexed condition, and to 1 intervention — of which ARCT-032 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06747858 reports 11 study locations spanning 10 distinct geographic areas — top geographies include Florida, Arizona, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06747858 about?

NCT06747858 is a clinical study titled "Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis". ARCT-032-02 is a Phase 2, open-label, multicenter, multiple-ascending dose study of ARCT-032 in adults with CF who are not eligible for CFTR modulator therapy or are not taking CFTR modulators due to drug intolerance, poor response, or lack of access to modulators.

What is the current status of trial NCT06747858?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 12 participants. The study started on 2024-12-12. Estimated completion is 2025-12.

What conditions does trial NCT06747858 study?

This clinical trial studies the following conditions: Cystic Fibrosis, CFTR Gene Mutation. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06747858?

The interventions under investigation include: ARCT-032 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06747858?

This trial is sponsored by Arcturus Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06747858 being conducted?

This trial has 11 study locations across Arizona, Arkansas, California, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial