Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections
NCT06702878 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 3 multi-center, group-randomized, crossover trial to compare nasal antimicrobial photodisinfection therapy (aPDT) with standard of care for prevention of surgical site infections in patients undergoing major elective, urgent, or emergent surgeries in a hospital setting. The main outcomes are to: 1. compare the efficacy, and 2. estimate the safety of applying nasal (aPDT) before surgery in reducing the incidence of SSIs within the initial 30 days after surgery compared to standard of care (SOC). Participants in the intervention group will receive aPDT prior to surgery on the day of surgery. Participants in the control group will receive standard of care surgical site prevention measures prior to surgery.
Conditions Studied
Interventions
- COMBINATION_PRODUCT nasal antimicrobial photodisinfection therapy
Study Locations (14)
Texas
- Medical City Frisco Hospital — Frisco
- HCA Houston Healthcare Kingwood — Kingwood
- Medical City Plano — Plano
- Methodist Metropolitan Hospital — San Antonio
- Methodist Main Hospital and Landmark — San Antonio
- Methodist Stone Oak — San Antonio
- HCA Houston Healthcare Clear Lake Hospital — Webster
Florida
- HCA Brandon Florida — Brandon
- HCA Florida Largo Hospital — Largo
- HCA Florida NorthSide Hospital — St. Petersburg
- HCA Florida Trinity Hospital — Trinity
Colorado
- Swedish Medical Center — Englewood
Tennessee
- Centennial Medical Center — Nashville
Virginia
- Johnston Willis Hospital — Richmond
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4,514 participants |
| Start Date | 2024-12-27 |
| Est. Completion | 2026-04-30 |
| Phase | Phase 3 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06702878
The ClinicalTrials.gov registry entry for NCT06702878 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 4,514 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ondine Biomedical, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Infections appearing as the primary indexed condition, and to 1 intervention — of which nasal antimicrobial photodisinfection therapy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06702878 reports 14 study locations spanning 5 distinct geographic areas — top geographies include Texas, Florida, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06702878 about?
NCT06702878 is a clinical study titled "Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections". This is a Phase 3 multi-center, group-randomized, crossover trial to compare nasal antimicrobial photodisinfection therapy (aPDT) with standard of care for prevention of surgical site infections in patients undergoing major elective, urgent, or emergent surgeries in a hospital setting. The main outc...
What is the current status of trial NCT06702878?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 4,514 participants. The study started on 2024-12-27. Estimated completion is 2026-04-30.
What conditions does trial NCT06702878 study?
This clinical trial studies the following conditions: Infections, Surgical Wound Infection, Surgical Site Infections, Anti-Infective Agents. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06702878?
The interventions under investigation include: nasal antimicrobial photodisinfection therapy (COMBINATION_PRODUCT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06702878?
This trial is sponsored by Ondine Biomedical, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06702878 being conducted?
This trial has 14 study locations across Colorado, Florida, Tennessee, Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.