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ACTIVE NOT RECRUITING Phase 3

A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84)

NCT06698042 · View on ClinicalTrials.gov ↗

Study Summary

Researchers are looking for new ways to treat non-small cell lung cancer (NSCLC) that is metastatic, which means cancer has spread to other parts of the body. Some people with metastatic NSCLC are treated with pembrolizumab, an immunotherapy treatment that is given into a vein as an intravenous (IV) infusion. Pembrolizumab (+) Berahyaluronidase alfa is pembrolizumab that is given under the skin as a subcutaneous (SC) injection. The goal of this study is to learn what happens to pembrolizumab in a person's body over time when it is given as an IV infusion or SC injection.

Interventions

  • BIOLOGICAL Pembrolizumab
  • BIOLOGICAL Pembrolizumab (+) Berahyaluronidase alfa

Study Locations (20)

Guangdong

  • The first affiliated hospital, Sun Yat-Sen university ( Site 5011) — Guangzhou
  • Southern Medical University Nanfang Hospital ( Site 5003) — Guangzhou
  • Huizhou Central People's Hospital ( Site 5004) — Huizhou
  • Jiangmen Center Hospital ( Site 5001) — Jiangmen

Fujian

  • Fujian Province Cancer Hospital ( Site 5007) — Fuzhou
  • The First Affiliated hospital of Xiamen University ( Site 5008) — Xiamen

Sichuan

  • West China Hospital of Sichuan University ( Site 5016) — Chengdu
  • Sichuan Cancer Hospital. ( Site 5006) — Chengdu

California

  • Providence Medical Foundation ( Site 0117) — Fullerton

Illinois

  • Illinois Cancer Care ( Site 0101) — Peoria

New York

  • Montefiore Medical Center ( Site 0104) — The Bronx

Ohio

  • University of Cincinnati Medical Center ( Site 0112) — Cincinnati

Beijing Municipality

  • Beijing Peking Union Medical College Hospital ( Site 5000) — Beijing

Trial Details

FieldValue
Enrollment Target 67 participants
Start Date 2024-11-21
Est. Completion 2030-02-11
Phase Phase 3

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06698042

The ClinicalTrials.gov registry entry for NCT06698042 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 67 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Lung Cancer appearing as the primary indexed condition, and to 2 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06698042 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Guangdong, Fujian, Sichuan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06698042 about?

NCT06698042 is a clinical study titled "A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84)". Researchers are looking for new ways to treat non-small cell lung cancer (NSCLC) that is metastatic, which means cancer has spread to other parts of the body. Some people with metastatic NSCLC are treated with pembrolizumab, an immunotherapy treatment that is given into a vein as an intravenous (IV...

What is the current status of trial NCT06698042?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 67 participants. The study started on 2024-11-21. Estimated completion is 2030-02-11.

What conditions does trial NCT06698042 study?

This clinical trial studies the following conditions: Lung Cancer, Non-Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06698042?

The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Pembrolizumab (+) Berahyaluronidase alfa (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06698042?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06698042 being conducted?

This trial has 20 study locations across California, Illinois, New York, Ohio, Beijing Municipality. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial