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RECRUITING

Restarting Triple Therapy With Robust Monitoring for Adverse Events (RETRIAL)

NCT06683092 · View on ClinicalTrials.gov ↗

Study Summary

RETRIAL is a multi-site observational study of people with Cystic Fibrosis (PWCF) ages 6 and up starting the new triple-therapy modulator (vanzacaftor/tezacaftor/deutivacaftor (VTD)), after having experienced neuropsychiatric events and/or liver injury while taking elexacaftor/tezacaftor/ivacaftor (ETI) that resulted in a modification or discontinuation of standard ETI dosing.

Conditions Studied

Interventions

  • OTHER RETRIAL-Mental Health
  • OTHER RETRIAL-Liver
  • OTHER RETRIAL-Neuro

Study Locations (18)

Florida

  • Nemours Children's — Jacksonville
  • Nemours Children's — Orlando
  • Nemours Children's — Pensacola

Colorado

  • Children's Hospital Colorado — Aurora
  • National Jewish Health — Denver

Massachusetts

  • Massachusetts General Hospital — Boston
  • Boston Children's Hospital — Boston

Alabama

  • University of Alabama at Birmingham — Birmingham

Delaware

  • Nemours Children's — Wilmington

Georgia

  • Emory University — Atlanta

Indiana

  • Indiana University — Bloomington

Kansas

  • Kansas University Medical Center — Kansas City

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2025-05-01
Est. Completion 2028-06

Sponsor

Boston Children's Hospital

752 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06683092

The ClinicalTrials.gov registry entry for NCT06683092 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Boston Children's Hospital, which has 752 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Cystic Fibrosis appearing as the primary indexed condition, and to 3 interventions — of which RETRIAL-Mental Health is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06683092 reports 18 study locations spanning 14 distinct geographic areas — top geographies include Florida, Colorado, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06683092 about?

NCT06683092 is a clinical study titled "Restarting Triple Therapy With Robust Monitoring for Adverse Events (RETRIAL)". RETRIAL is a multi-site observational study of people with Cystic Fibrosis (PWCF) ages 6 and up starting the new triple-therapy modulator (vanzacaftor/tezacaftor/deutivacaftor (VTD)), after having experienced neuropsychiatric events and/or liver injury while taking elexacaftor/tezacaftor/ivacaftor (...

What is the current status of trial NCT06683092?

This trial is currently recruiting. The enrollment target is 200 participants. The study started on 2025-05-01. Estimated completion is 2028-06.

What conditions does trial NCT06683092 study?

This clinical trial studies the following conditions: Cystic Fibrosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06683092?

The interventions under investigation include: RETRIAL-Mental Health (OTHER), RETRIAL-Liver (OTHER), RETRIAL-Neuro (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06683092?

This trial is sponsored by Boston Children's Hospital, which has 752 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06683092 being conducted?

This trial has 18 study locations across Alabama, Colorado, Delaware, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial