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NCT06678737 · ClinicalTrials.gov registry record · Phase 2
CBIT+TMS R33 Phase
A Phase 2 study of Tourette Syndrome and Tics, sponsored by University of Minnesota.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06678737: Recruiting Phase 2 study of Tourette Syndrome and Tics, sponsored by University of Minnesota.
NCT06678737 is a Phase 2 study of Tourette Syndrome and Tics that is actively recruiting participants, run by University of Minnesota. The registered enrollment target is 60 participants, below the 85-participant average among 33 other Tourette Syndrome trials with a reported enrollment target (29% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06678737, a Phase 2 study of Tourette Syndrome and Tics, is actively recruiting participants, sponsored by University of Minnesota.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
Chronic tics are a disabling neuropsychiatric symptom associated with multiple child-onset mental disorders. Chronic tics affect 1-3% of youth 1 and are associated with impaired functioning, emotional and behavioral problems, physical pain, diminished quality of life, peer victimization, and a fourfold increased risk of suicide compared to the general population. Large randomized trials have demonstrated the superiority of CBIT over supportive therapy in child and adult patients. However, in these trials, only 52% of children and 38% of adults showed clinically meaningful tic improvement, meaning that 50-60% of patients do not benefit from CBIT. CBIT success relies on an ability to suppress tics that many youth lack. The central aim of CBIT is to enhance voluntary tic suppression. Better tic suppression ability drives CBIT improvement 10 and predicts lower tic burden over the course of illness. During the core CBIT procedure, competing response training, patients learn to inhibit tics by engaging in a competing motor action. However, research shows that many youth lack this fundamental tic suppression ability that CBIT aspires to enhance. This study will examine the clinical and neural effects of a treatment combining Comprehensive Behavioral Intervention for Tics (CBIT) and transcranial magnetic stimulation (TMS) to the supplementary motor area (SMA) in young people with tic disorder.
Primary Outcome
Yale Global Tic Severity Scale, YGTSS: Gold-standard, clinician-administered tic severity scale. Includes symptom checklist of specific tic types.
Conditions Studied
Interventions
- OTHER CBIT +cTBS
- OTHER CBIT +sham cTBS
Study Locations (1)
Minnesota
- University of Minnesota - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-02-27 |
| Est. Completion | 2030-07-15 |
| Phase | Phase 2 |
What NCT06678737 shows while recruiting
NCT06678737 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 85-participant average among 33 other Tourette Syndrome trials with a reported enrollment target (29% lower).
The record links to 2 conditions, with Tourette Syndrome appearing as the primary indexed condition, and to 2 interventions - of which CBIT +cTBS is the first listed.
NCT06678737 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT06678737 about?
NCT06678737 is a clinical study titled "CBIT+TMS R33 Phase". Chronic tics are a disabling neuropsychiatric symptom associated with multiple child-onset mental disorders. Chronic tics affect 1-3% of youth 1 and are associated with impaired functioning, emotional and behavioral problems, physical pain, diminished quality of life, peer victimization, and a fourf...
What is the current status of trial NCT06678737?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2025-02-27. Estimated completion is 2030-07-15.
What conditions does trial NCT06678737 study?
This clinical trial studies the following conditions: Tourette Syndrome, Tics.
What interventions are being tested in trial NCT06678737?
The interventions under investigation include: CBIT +cTBS (OTHER), CBIT +sham cTBS (OTHER).
Who is sponsoring clinical trial NCT06678737?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06678737 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tourette Syndrome
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06678737's enrollment target sits among peer trials
60 15th of 33 higher than 19 of 33 other Tourette Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tourette Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics
RECRUITING · Phase 2
-
Efficacy and Safety of Gemlapodect (NOE-105) in Adults and Adolescents With Tourette Syndrome
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Pramipexole Pilot Phase II Study in Children and Adolescents With Tourette Disorder According to DSM-IV Criteria
COMPLETED · Phase 2
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Transcranial Magnetic Stimulation (TMS) for Individuals With Tourette's Syndrome
COMPLETED · Phase 2
-
Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children
COMPLETED · Phase 2
-
Sensorimotor and Psychosocial Trajectories in Adolescents With Tic Disorder
RECRUITING
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