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NCT06638307 · ClinicalTrials.gov registry record · Phase 1
A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer
A Phase 1 study of Advanced Breast Cancer, sponsored by Stemline Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 240
- Enrollment target
- 20
- Study locations
NCT06638307: Recruiting Phase 1 study of Advanced Breast Cancer, sponsored by Stemline Therapeutics.
NCT06638307 is a Phase 1 study of Advanced Breast Cancer that is actively recruiting participants, run by Stemline Therapeutics. The registered enrollment target is 240 participants, below the 456-participant average among 28 other Advanced Breast Cancer trials with a reported enrollment target (47% lower). The trial reports 20 study locations across 12 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06638307, a Phase 1 study of Advanced Breast Cancer, is actively recruiting participants, sponsored by Stemline Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 240 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a first-in-human study of MEN2312, a lysine acetyltransferase 6 (KAT6) inhibitor, in adult participants with advanced breast cancer.
Conditions Studied
Interventions
- DRUG Elacestrant
- DRUG MEN2312
Study Locations (20)
Florida
- Advent Health Orlando - Altamonte Springs
- Sarah Cannon Research Institute at Florida Cancer Specialists - Orlando
- Florida Cancer Specialists & Research Institute (FCS) - Sarasota - Sarasota
- Moffitt Cancer Center - Tampa
California
- UC San Diego Moores Cancer Center - La Jolla
- UCSF Helen Diller Family Comprehensive Cancer Center - San Francisco
- UCLA Hematology Oncology - Parkside - Santa Monica
New York
- Perlmutter Cancer Center - Sunset Park - Brooklyn
- Perlmutter Cancer Center at NYU Langone Hospital - Long Island - Mineola
- Laura & Isaac Perlmutter Cancer Center at NYU Langone Health - New York
Massachusetts
- Massachusetts General Hospital Cancer Center - Boston
- Dana-Farber Cancer Institute - Boston
Arkansas
- Highlands Oncology Group - Springdale
Connecticut
- Yale Comprehensive Cancer Center - New Haven
Georgia
- Winship Cancer Institute, Emory University - Atlanta
Maryland
- Sidney Kimmel Comprehensive Cancer Center - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2024-10-25 |
| Est. Completion | 2026-10 |
| Phase | Phase 1 |
What NCT06638307 shows while recruiting
NCT06638307 is an interventional study that assigns participants to a tested intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, below the 456-participant average among 28 other Advanced Breast Cancer trials with a reported enrollment target (47% lower).
The record links to 1 condition, with Advanced Breast Cancer appearing as the primary indexed condition, and to 2 interventions - of which Elacestrant is the first listed.
NCT06638307 names 20 study sites across 12 states, led by Florida, California, New York.
Frequently Asked Questions
What is clinical trial NCT06638307 about?
NCT06638307 is a clinical study titled "A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer". This is a first-in-human study of MEN2312, a lysine acetyltransferase 6 (KAT6) inhibitor, in adult participants with advanced breast cancer.
What is the current status of trial NCT06638307?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 240 participants. The study started on 2024-10-25. Estimated completion is 2026-10.
What conditions does trial NCT06638307 study?
This clinical trial studies the following conditions: Advanced Breast Cancer.
What interventions are being tested in trial NCT06638307?
The interventions under investigation include: Elacestrant (DRUG), MEN2312 (DRUG).
Who is sponsoring clinical trial NCT06638307?
This trial is sponsored by Stemline Therapeutics, which has 17 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06638307 being conducted?
This trial has 20 study locations across Arkansas, California, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Advanced Breast Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06638307's enrollment target sits among peer trials
240 12th of 28 higher than 17 of 28 other Advanced Breast Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Advanced Breast Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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