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ACTIVE NOT RECRUITING Phase 3

Phase 3 Study of Daraxonrasib (RMC-6236) in Patients With Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)

NCT06625320 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard(s) of care (SOC) treatment.

Interventions

  • DRUG Gemcitabine
  • DRUG Irinotecan
  • DRUG nab-paclitaxel
  • DRUG RMC-6236
  • DRUG Liposomal irinotecan

Study Locations (20)

California

  • City of Hope-Duarte — Duarte
  • Cedars-Sinai Medical Center — Los Angeles
  • UCLA — Los Angeles
  • UC San Diego Health Moores Cancer Center — San Diego
  • Mission Hall UCSF — San Francisco

Florida

  • Mayo Clinic Cancer Center - Florida — Jacksonville
  • University of Miami Sylvester Comprehensive Cancer Center — Miami
  • Cancer Care Centers of Brevard Inc — Palm Bay
  • Moffitt Cancer Center — Tampa

Arizona

  • Banner MD Anderson Cancer Center — Gilbert
  • Mayo Clinic Cancer Center - Phoenix — Phoenix

Michigan

  • University of Michigan — Ann Arbor
  • Karmanos Cancer Institute — Detroit

Colorado

  • Rocky Mountain Cancer — Aurora

Hawaii

  • The Queen's Medical Center — Honolulu

Illinois

  • The University of Chicago Medical Center — Chicago

Maryland

  • Johns Hopkins — Baltimore

Trial Details

FieldValue
Enrollment Target 501 participants
Start Date 2024-10-16
Est. Completion 2027-12
Phase Phase 3

Sponsor

Revolution Medicines

66 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06625320

The ClinicalTrials.gov registry entry for NCT06625320 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 501 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Revolution Medicines, which has 66 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Pancreatic Cancer appearing as the primary indexed condition, and to 5 interventions — of which Gemcitabine is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06625320 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Florida, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06625320 about?

NCT06625320 is a clinical study titled "Phase 3 Study of Daraxonrasib (RMC-6236) in Patients With Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)". The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard(s) of care (SOC) treatment.

What is the current status of trial NCT06625320?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 501 participants. The study started on 2024-10-16. Estimated completion is 2027-12.

What conditions does trial NCT06625320 study?

This clinical trial studies the following conditions: Pancreatic Cancer, PDAC - Pancreatic Ductal Adenocarcinoma, PDAC. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06625320?

The interventions under investigation include: Gemcitabine (DRUG), Irinotecan (DRUG), nab-paclitaxel (DRUG), RMC-6236 (DRUG), Liposomal irinotecan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06625320?

This trial is sponsored by Revolution Medicines, which has 66 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06625320 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Florida, Hawaii. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial