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Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
NCT06608927 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to compare overall survival of quemliclustat, nab-paclitaxel and gemcitabine versus placebo, nab-paclitaxel and gemcitabine in all randomized patients.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Gemcitabine
- DRUG Quemliclustat
- DRUG Nab-paclitaxel
Study Locations (20)
California
- University of California San Diego Health — La Jolla
- Cancer & Blood Specialty Clinic - Los Alamitos — Los Alamitos
- Keck Medicine of USC - Keck Hospital of USC — Los Angeles
- Sutter Medical Center — Roseville
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco
- UCLA Health - Santa Monica Cancer Care — Santa Monica
Arizona
- Mayo Clinic Arizona - Phoenix Campus — Phoenix
- University of Arizona Cancer Center — Tucson
Florida
- Mayo Clinic - Jacksonville — Jacksonville
- Miami Cancer Institute — Miami
Georgia
- Piedmont Cancer Institute — Atlanta
- Emory University Hospital — Atlanta
Illinois
- USOR - Illinois Cancer Specialists - Arlington Heights — Arlington Heights
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University — Chicago
Colorado
- USOR - Rocky Mountain Cancer Centers - Denver - Midtown — Denver
Connecticut
- Yale Cancer Center — New Haven
Indiana
- Indiana University Melvin and Bren Simon Cancer Center — Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 610 participants |
| Start Date | 2024-12-13 |
| Est. Completion | 2030-11-30 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06608927
The ClinicalTrials.gov registry entry for NCT06608927 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 610 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Arcus Biosciences, which has 14 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Metastatic Pancreatic Ductal Adenocarcinoma appearing as the primary indexed condition, and to 4 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06608927 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Arizona, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06608927 about?
NCT06608927 is a clinical study titled "Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma". The purpose of this study is to compare overall survival of quemliclustat, nab-paclitaxel and gemcitabine versus placebo, nab-paclitaxel and gemcitabine in all randomized patients.
What is the current status of trial NCT06608927?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 610 participants. The study started on 2024-12-13. Estimated completion is 2030-11-30.
What conditions does trial NCT06608927 study?
This clinical trial studies the following conditions: Metastatic Pancreatic Ductal Adenocarcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06608927?
The interventions under investigation include: Placebo (DRUG), Gemcitabine (DRUG), Quemliclustat (DRUG), Nab-paclitaxel (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06608927?
This trial is sponsored by Arcus Biosciences, which has 14 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06608927 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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