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NCT06601933 · ClinicalTrials.gov registry record · Phase 2
Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial
A Phase 2 study of Mild Cognitive Impairment (MCI) and Cognitive Training, sponsored by Columbia University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 240
- Enrollment target
- 4
- Study locations
NCT06601933: Recruiting Phase 2 study of Mild Cognitive Impairment (MCI) and Cognitive Training, sponsored by Columbia University.
NCT06601933 is a Phase 2 study of Mild Cognitive Impairment (MCI) and Cognitive Training that is actively recruiting participants, run by Columbia University. The registered enrollment target is 240 participants, above the 147-participant average among 19 other Mild Cognitive Impairment (MCI) trials with a reported enrollment target (63% higher). The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06601933, a Phase 2 study of Mild Cognitive Impairment (MCI) and Cognitive Training, is actively recruiting participants, sponsored by Columbia University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 240 participants
- Enrollment target
- 4
- Study locations
Study Summary
Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia. Cognitive training represents an important therapeutic strategy. In a previous study, crossword puzzles were found to be superior to computerized cognitive training on the primary cognitive outcome and function with decreased brain atrophy. Building on these findings, this study will evaluate and compare the impact of high dose crosswords (4 puzzles per week) to low dose crosswords (1 puzzle per week) and a health education control group on the cognition and function of participants.
Primary Outcome
The ADASCog-14 is a brief neuropsychological assessment used to assess the severity of cognitive symptoms of dementia. It is one of the most widely used cognitive scales in clinical trials and is considered to be the "gold standard" for assessing antidementia treatments. The total score range is 0 to 90; a higher score indicates greater cognitive impairment.
Conditions Studied
Interventions
- OTHER Cognitive Training
Study Locations (4)
Florida
- University of Miami Miller School of Medicine - Miami
New York
- Columbia University Irving Medical Center - New York
North Carolina
- Duke University Medical Center - Durham
Washington
- University of Washington - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2024-12-17 |
| Est. Completion | 2029-02-28 |
| Phase | Phase 2 |
What NCT06601933 shows while recruiting
NCT06601933 is an interventional study that assigns participants to a tested intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, above the 147-participant average among 19 other Mild Cognitive Impairment (MCI) trials with a reported enrollment target (63% higher).
The record links to 2 conditions, with Mild Cognitive Impairment (MCI) appearing as the primary indexed condition, and to 1 intervention - of which Cognitive Training is the first listed.
NCT06601933 reports a single indexed study location in Florida, New York, North Carolina.
Frequently Asked Questions
What is clinical trial NCT06601933 about?
NCT06601933 is a clinical study titled "Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial". Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia. Cognitive training represents an important therapeutic strategy. In a previous study, crossword puzzles were found to be super...
What is the current status of trial NCT06601933?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 240 participants. The study started on 2024-12-17. Estimated completion is 2029-02-28.
What conditions does trial NCT06601933 study?
This clinical trial studies the following conditions: Mild Cognitive Impairment (MCI), Cognitive Training.
What interventions are being tested in trial NCT06601933?
The interventions under investigation include: Cognitive Training (OTHER).
Who is sponsoring clinical trial NCT06601933?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06601933 being conducted?
This trial has 4 study locations across Florida, New York, North Carolina, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mild Cognitive Impairment (MCI)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06601933's enrollment target sits among peer trials
240 3rd of 19 higher than 16 of 19 other Mild Cognitive Impairment (MCI) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mild Cognitive Impairment (MCI) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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