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NCT07097051 · ClinicalTrials.gov registry record · Phase 2
Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment
A Phase 2 study of Mild Cognitive Impairment (MCI), sponsored by High Point University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT07097051: Recruiting Phase 2 study of Mild Cognitive Impairment (MCI), sponsored by High Point University.
NCT07097051 is a Phase 2 study of Mild Cognitive Impairment (MCI) that is actively recruiting participants, run by High Point University. The registered enrollment target is 20 participants, below the 158-participant average among 19 other Mild Cognitive Impairment (MCI) trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07097051, a Phase 2 study of Mild Cognitive Impairment (MCI), is actively recruiting participants, sponsored by High Point University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
Older adults with Mild Cognitive Impairment (MCI) often show less brain activity in a specific range (8-13 Hz, known as alpha power) compared to healthy older adults. Those with lower alpha activity, especially in the front part of the brain, usually have problems with executive functions like planning and multitasking. Our research has shown that older adults with lower alpha power in these areas also struggle more with balance when they have to do two things at once (like standing and performing a cognitive task simultaneously). The investigators believe that increasing alpha power in older adults with MCI could improve their balance and executive function, helping them stay independent longer. In early studies, the investigators found that using transcranial alternating current stimulation (tACS) at 10 Hz on the front part of the brain can boost alpha power and balance immediately after a single session in older adults with MCI. The effect was stronger in those whose natural brain activity was close to the 10 Hz stimulation. Based on these findings, the investigators plan to conduct a pilot study with older adults aged 65-85 years with MCI. Participants will be randomly assigned to receive either real tACS or a sham (placebo) treatment. Our main hypothesis is that real tACS will improve balance when multitasking, and these improvements will last for 1 to 3 months after the treatment. The investigators also believe that tACS will enhance other aspects of executive function and mobility and that these improvements will be linked to increased alpha activity in the brain. Through this study, we aim to gather strong evidence that tailored tACS is a promising treatment to improve cognitive and motor functions and overall brain activity in older adults with MCI.
Primary Outcome
Change of EEG oscillations and frequency coupling at 8-13 Hz
Conditions Studied
Interventions
- OTHER real tACS
- OTHER sham tACS
Study Locations (1)
North Carolina
- High Point University - High Point
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-05-13 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 2 |
What NCT07097051 shows while recruiting
NCT07097051 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 158-participant average among 19 other Mild Cognitive Impairment (MCI) trials with a reported enrollment target (87% lower).
The record links to 1 condition, with Mild Cognitive Impairment (MCI) appearing as the primary indexed condition, and to 2 interventions - of which real tACS is the first listed.
NCT07097051 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT07097051 about?
NCT07097051 is a clinical study titled "Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment". Older adults with Mild Cognitive Impairment (MCI) often show less brain activity in a specific range (8-13 Hz, known as alpha power) compared to healthy older adults. Those with lower alpha activity, especially in the front part of the brain, usually have problems with executive functions like plann...
What is the current status of trial NCT07097051?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2025-05-13. Estimated completion is 2026-12-31.
What conditions does trial NCT07097051 study?
This clinical trial studies the following conditions: Mild Cognitive Impairment (MCI).
What interventions are being tested in trial NCT07097051?
The interventions under investigation include: real tACS (OTHER), sham tACS (OTHER).
Who is sponsoring clinical trial NCT07097051?
This trial is sponsored by High Point University, which has 10 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07097051 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mild Cognitive Impairment (MCI)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07097051's enrollment target sits among peer trials
20 14th of 19 higher than 6 of 19 other Mild Cognitive Impairment (MCI) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mild Cognitive Impairment (MCI) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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