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Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Psoriatic Arthritis and Obesity or Overweight
NCT06588296 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of this study is to demonstrate that when participants with psoriatic arthritis and obesity or overweight in the presence of at least 1 weight-related comorbid condition receive ixekizumab and tirzepatide concomitantly administered, participants see improvement in their psoriatic arthritis and achieve weight reduction compared to when receiving ixekizumab. Participation in this study includes up to 12 visits and could last up to 61 weeks including screening, open label treatment period, and post-treatment follow-up period.
Conditions Studied
Interventions
- DRUG Tirzepatide
- DRUG Ixekizumab
Study Locations (20)
Arizona
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Avondale — Avondale
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler — Chandler
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff — Flagstaff
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Gilbert — Gilbert
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Glendale — Glendale
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Mesa — Mesa
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Phoenix PV — Phoenix
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Sun City — Sun City
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson — Tucson
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson Southeast — Tucson
California
- Medvin Clinical Research - Apple Valley — Apple Valley
- Medvin Clinical Research - Covina — Covina
- Newport Huntington Medical Group — Huntington Beach
- Purushotham & Akther Kotha MD, Inc — La Mesa
- Medvin Clinical Research - Riverside — Riverside
- Rheumatology Center of San Diego — San Diego
- Medvin Clinical Research - Temecula — Temecula
- Cohen Medical Centers — Thousand Oaks
- Medvin Clinical Research - Tujunga — Tujunga
- Medvin Clinical Research - Whittier — Whittier
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 279 participants |
| Start Date | 2024-09-24 |
| Est. Completion | 2026-04 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06588296
The ClinicalTrials.gov registry entry for NCT06588296 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 279 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions — of which Tirzepatide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06588296 reports 20 study locations spanning 2 distinct geographic areas — top geographies include Arizona, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06588296 about?
NCT06588296 is a clinical study titled "Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Psoriatic Arthritis and Obesity or Overweight". The main purpose of this study is to demonstrate that when participants with psoriatic arthritis and obesity or overweight in the presence of at least 1 weight-related comorbid condition receive ixekizumab and tirzepatide concomitantly administered, participants see improvement in their psoriatic ar...
What is the current status of trial NCT06588296?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 279 participants. The study started on 2024-09-24. Estimated completion is 2026-04.
What conditions does trial NCT06588296 study?
This clinical trial studies the following conditions: Obesity, Psoriatic Arthritis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06588296?
The interventions under investigation include: Tirzepatide (DRUG), Ixekizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06588296?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06588296 being conducted?
This trial has 20 study locations across Arizona, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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