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NCT06585709 · ClinicalTrials.gov registry record · NA

OUD (Opioid Use Disorder) Target Trial

A NA study of Opioid Use Disorder, sponsored by Duke University.

Recruiting
Registry status
NA
Development phase
80
Enrollment target
1
Study location

NCT06585709 is a NA study of Opioid Use Disorder that is actively recruiting participants, run by Duke University. The registered enrollment target is 80 participants, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06585709, a NA study of Opioid Use Disorder, is actively recruiting participants, sponsored by Duke University.

RECRUITING
Registry status
NA
Development phase
80 participants
Enrollment target
1
Study location

Study Summary

In this research study the investigators will work with 80-participants with opioid use disorder who are starting treatment with the medication buprenorphine and are trying to quit using opioids. The investigators are trying to learn two things: 1. Can an MRI brain marker be used to predict which participants will be successful in quitting opioids with buprenorphine? 2. Does adjunctive treatment with repetitive Transcranial Magnetic Stimulation (rTMS) help people quit using opioids more than a sham (placebo) version of rTMS? In order to complete the study the investigators will ask participants to: * Complete an MRI within 5-days of starting buprenorphine and again after they are on a full stable dose 1-3 weeks later. * Undergo study-treatment with 30-sessions of either real or placebo rTMS in as little as 1-week (10-sessions-per-day for five days) or as long as over 6-weeks. * Meet with the investigators once per week over the following 12-weeks to see if the participants have been able to quit using opioids over that time.

Conditions Studied

Opioid Use Disorder

Interventions

  • DEVICE Sham repetitive Transcranial Magnetic Stimulation (rTMS)
  • DEVICE Active repetitive Transcranial Magnetic Stimulation (rTMS)
  • DIAGNOSTIC_TEST High Ventral Striatal Reactivity
  • DIAGNOSTIC_TEST Low Ventral Striatal Reactivity

Study Locations (1)

North Carolina

  • Duke University - Durham

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2024-12-31
Est. Completion 2026-10-31
Phase NA

Sponsor

Duke University

1,725 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06585709

The ClinicalTrials.gov registry entry for NCT06585709 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (98% lower). The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Opioid Use Disorder appearing as the primary indexed condition, and to 4 interventions - of which Sham repetitive Transcranial Magnetic Stimulation (rTMS) is the first listed.

NCT06585709 reports 1 study location spanning 1 distinct geographic area - top geographies include North Carolina.

Frequently Asked Questions

What is clinical trial NCT06585709 about?

NCT06585709 is a clinical study titled "OUD (Opioid Use Disorder) Target Trial". In this research study the investigators will work with 80-participants with opioid use disorder who are starting treatment with the medication buprenorphine and are trying to quit using opioids. The investigators are trying to learn two things: 1. Can an MRI brain marker be used to predict which ...

What is the current status of trial NCT06585709?

This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2024-12-31. Estimated completion is 2026-10-31.

What conditions does trial NCT06585709 study?

This clinical trial studies the following conditions: Opioid Use Disorder.

What interventions are being tested in trial NCT06585709?

The interventions under investigation include: Sham repetitive Transcranial Magnetic Stimulation (rTMS) (DEVICE), Active repetitive Transcranial Magnetic Stimulation (rTMS) (DEVICE), High Ventral Striatal Reactivity (DIAGNOSTIC_TEST), Low Ventral Striatal Reactivity (DIAGNOSTIC_TEST).

Who is sponsoring clinical trial NCT06585709?

This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06585709 being conducted?

This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.