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NCT06585709 · ClinicalTrials.gov registry record · NA
OUD (Opioid Use Disorder) Target Trial
A NA study of Opioid Use Disorder, sponsored by Duke University.
- Recruiting
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT06585709: Recruiting NA study of Opioid Use Disorder, sponsored by Duke University.
NCT06585709 is a NA study of Opioid Use Disorder that is actively recruiting participants, run by Duke University. The registered enrollment target is 80 participants, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06585709, a NA study of Opioid Use Disorder, is actively recruiting participants, sponsored by Duke University.
- RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
In this research study the investigators will work with 80-participants with opioid use disorder who are starting treatment with the medication buprenorphine and are trying to quit using opioids. The investigators are trying to learn two things: 1. Can an MRI brain marker be used to predict which participants will be successful in quitting opioids with buprenorphine? 2. Does adjunctive treatment with repetitive Transcranial Magnetic Stimulation (rTMS) help people quit using opioids more than a sham (placebo) version of rTMS? In order to complete the study the investigators will ask participants to: * Complete an MRI within 5-days of starting buprenorphine and again after they are on a full stable dose 1-3 weeks later. * Undergo study-treatment with 30-sessions of either real or placebo rTMS in as little as 1-week (10-sessions-per-day for five days) or as long as over 6-weeks. * Meet with the investigators once per week over the following 12-weeks to see if the participants have been able to quit using opioids over that time.
Primary Outcome
The number of participants who have not met relapse criteria in the 12-week follow-up phase. Relapse is defined as a) any opioid use in 4 consecutive weeks, or b) any opioid use on 7 consecutive days.
Conditions Studied
Interventions
- DEVICE Sham repetitive Transcranial Magnetic Stimulation (rTMS)
- DEVICE Active repetitive Transcranial Magnetic Stimulation (rTMS)
- DIAGNOSTIC_TEST High Ventral Striatal Reactivity
- DIAGNOSTIC_TEST Low Ventral Striatal Reactivity
Study Locations (1)
North Carolina
- Duke University - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2024-12-31 |
| Est. Completion | 2026-10-31 |
| Phase | NA |
What NCT06585709 shows while recruiting
NCT06585709 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Opioid Use Disorder appearing as the primary indexed condition, and to 4 interventions - of which Sham repetitive Transcranial Magnetic Stimulation (rTMS) is the first listed.
NCT06585709 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT06585709 about?
NCT06585709 is a clinical study titled "OUD (Opioid Use Disorder) Target Trial". In this research study the investigators will work with 80-participants with opioid use disorder who are starting treatment with the medication buprenorphine and are trying to quit using opioids. The investigators are trying to learn two things: 1. Can an MRI brain marker be used to predict which ...
What is the current status of trial NCT06585709?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2024-12-31. Estimated completion is 2026-10-31.
What conditions does trial NCT06585709 study?
This clinical trial studies the following conditions: Opioid Use Disorder.
What interventions are being tested in trial NCT06585709?
The interventions under investigation include: Sham repetitive Transcranial Magnetic Stimulation (rTMS) (DEVICE), Active repetitive Transcranial Magnetic Stimulation (rTMS) (DEVICE), High Ventral Striatal Reactivity (DIAGNOSTIC_TEST), Low Ventral Striatal Reactivity (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT06585709?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06585709 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06585709's enrollment target sits among peer trials
80 143rd of 257 higher than 113 of 257 other Opioid Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Opioid Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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