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NCT06495918 · ClinicalTrials.gov registry record · Phase 3
Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects With Neovascular Age- Related Macular Degeneration
A Phase 3 study of Neovascular Age-related Macular Degeneration, sponsored by Ocular Therapeutix.
- Active
- Registry status
- Phase 3
- Development phase
- 825
- Enrollment target
- 20
- Study locations
NCT06495918: Active Phase 3 study of Neovascular Age-related Macular Degeneration, sponsored by Ocular Therapeutix.
NCT06495918 is a Phase 3 study of Neovascular Age-related Macular Degeneration that is active but no longer recruiting, run by Ocular Therapeutix. The registered enrollment target is 825 participants, above the 384-participant average among 33 other Neovascular Age-related Macular Degeneration trials with a reported enrollment target (115% higher). The trial reports 20 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06495918, a Phase 3 study of Neovascular Age-related Macular Degeneration, is active but no longer recruiting, sponsored by Ocular Therapeutix.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 825 participants
- Enrollment target
- 20
- Study locations
Study Summary
Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects with Neovascular Age- Related Macular Degeneration
Primary Outcome
Mean change in Best Corrected Visual Acuity (BCVA) from baseline at Week 48
Conditions Studied
Interventions
- DRUG Aflibercept
- DRUG OTX-TKI
Study Locations (20)
California
- California Retina Consultants - Bakersfield
- The Retina Partners - Encino
- Retina Consultants of Orange County - Fullerton
- Atlantis Eyecare - Huntington Beach
- Salehi Retina Institute, Inc., dba Retina Associates of Southern California - Huntington Beach
- Kaiser Permanente Division of Research - Oakland
- California Retina Consultants - Oxnard
- Stanford Health Care - Byers Eye Institute - Palo Alto
- Stanford University School of Medicine, Byers Eye Institute - Palo Alto
- California Eye Specialists Medical Group, INC - Pasadena
- Retinal Consultants Medical Group - Sacramento
- Orange County Retina Medical Group - Santa Ana
- California Retina Consultants - Santa Barbara
- Macula Retina Vitreous Research Institute - Torrance
- Bay Area Retina Associates - Walnut Creek
Arizona
- Associated Retina Consultant - Gilbert
- Associated Retina Consultants, Ltd. - Phoenix
- Retinal Research Institute, LLC - Phoenix
- Retina Macula Institute of Arizona - Scottsdale
Colorado
- Retina Consultants of Southern Colorado - Colorado Springs
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 825 participants |
| Start Date | 2024-11-27 |
| Est. Completion | 2027-01-08 |
| Phase | Phase 3 |
What the registry record for NCT06495918 still lists
NCT06495918 is an interventional study that assigns participants to a tested intervention. The registered 825 participants enrollment target is mid-sized for trials with a published cap, above the 384-participant average among 33 other Neovascular Age-related Macular Degeneration trials with a reported enrollment target (115% higher).
The record links to 1 condition, with Neovascular Age-related Macular Degeneration appearing as the primary indexed condition, and to 2 interventions - of which Aflibercept is the first listed.
NCT06495918 names 20 study sites across 3 states, led by California, Arizona, Colorado.
Frequently Asked Questions
What is clinical trial NCT06495918 about?
NCT06495918 is a clinical study titled "Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects With Neovascular Age- Related Macular Degeneration". Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects with Neovascular Age- Related Macular Degeneration
What is the current status of trial NCT06495918?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 825 participants. The study started on 2024-11-27. Estimated completion is 2027-01-08.
What conditions does trial NCT06495918 study?
This clinical trial studies the following conditions: Neovascular Age-related Macular Degeneration.
What interventions are being tested in trial NCT06495918?
The interventions under investigation include: Aflibercept (DRUG), OTX-TKI (DRUG).
Who is sponsoring clinical trial NCT06495918?
This trial is sponsored by Ocular Therapeutix, which has 20 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06495918 being conducted?
This trial has 20 study locations across Arizona, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06495918's enrollment target sits among peer trials
825 4th of 33 higher than 30 of 33 other Neovascular Age-related Macular Degeneration trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Neovascular Age-related Macular Degeneration trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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