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NCT06491550 · ClinicalTrials.gov registry record · Phase 1
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 as Well as the Impact of AZD4144 on the Pharmacokinetics of Rosuvastatin and Furosemide in Healthy Participants
A Phase 1 study of Healthy Participants, sponsored by AstraZeneca.
- Completed
- Registry status
- Phase 1
- Development phase
- 91
- Enrollment target
- 2
- Study locations
NCT06491550: Completed Phase 1 study of Healthy Participants, sponsored by AstraZeneca.
NCT06491550 is a Phase 1 study of Healthy Participants that has completed, run by AstraZeneca. The registered enrollment target is 91 participants, above the 65-participant average among 119 other Healthy Participants trials with a reported enrollment target (40% higher). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06491550, a Phase 1 study of Healthy Participants, has completed, sponsored by AstraZeneca.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 91 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study consists of 3 parts: Part A, Part B and Part C. This study will compare the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of AZD4144 with placebo in healthy participants, in Part A and Part B. Part C of this study will investigate the possibility of drug-drug interaction (DDI) between IV AZD4144 and oral rosuvastatin and furosemide by evaluating the PK of rosuvastatin and furosemide when administered alone and in combination with single IV dose of AZD4144
Primary Outcome
To assess the safety and tolerability of AZD4144 following IV administration of single (Part A) and multiple (Part B) ascending doses in healthy participants.
Conditions Studied
Interventions
- DRUG AZD4144- Part A
- DRUG Placebo- Part A
- DRUG AZD4144- Part B
- DRUG Placebo- Part B
- DRUG Rosuvastatin and Furosemide- Part C
Study Locations (2)
California
- Research Site - Glendale
Maryland
- Research Site - Brooklyn
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 91 participants |
| Start Date | 2024-07-15 |
| Est. Completion | 2025-06-11 |
| Phase | Phase 1 |
What the finished NCT06491550 record still lists
NCT06491550 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 91 participants, a relatively small participant target, above the 65-participant average among 119 other Healthy Participants trials with a reported enrollment target (40% higher).
The record links to 1 condition, with Healthy Participants appearing as the primary indexed condition, and to 5 interventions - of which AZD4144- Part A is the first listed.
NCT06491550 reports a single indexed study location in California, Maryland.
Frequently Asked Questions
What is clinical trial NCT06491550 about?
NCT06491550 is a clinical study titled "A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 as Well as the Impact of AZD4144 on the Pharmacokinetics of Rosuvastatin and Furosemide in Healthy Participants". This study consists of 3 parts: Part A, Part B and Part C. This study will compare the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of AZD4144 with placebo in healthy participants, in Part A and Part B. Part C of this study will investigate the possibility of drug-drug inte...
What is the current status of trial NCT06491550?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 91 participants. The study started on 2024-07-15. Estimated completion is 2025-06-11.
What conditions does trial NCT06491550 study?
This clinical trial studies the following conditions: Healthy Participants.
What interventions are being tested in trial NCT06491550?
The interventions under investigation include: AZD4144- Part A (DRUG), Placebo- Part A (DRUG), AZD4144- Part B (DRUG), Placebo- Part B (DRUG), Rosuvastatin and Furosemide- Part C (DRUG).
Who is sponsoring clinical trial NCT06491550?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06491550 being conducted?
This trial has 2 study locations across California, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06491550's enrollment target sits among peer trials
91 28th of 119 higher than 92 of 119 other Healthy Participants trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy Participants trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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