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NCT06457919 · ClinicalTrials.gov registry record · Phase 1
A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer
A Phase 1 study of Prostate Cancer, sponsored by Memorial Sloan Kettering Cancer Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 50
- Enrollment target
- 12
- Study locations
NCT06457919: Recruiting Phase 1 study of Prostate Cancer, sponsored by Memorial Sloan Kettering Cancer Center.
NCT06457919 is a Phase 1 study of Prostate Cancer that is actively recruiting participants, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 50 participants, below the 608-participant average among 735 other Prostate Cancer trials with a reported enrollment target (92% lower). The trial reports 12 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06457919, a Phase 1 study of Prostate Cancer, is actively recruiting participants, sponsored by Memorial Sloan Kettering Cancer Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 50 participants
- Enrollment target
- 12
- Study locations
Study Summary
The purpose of this study is to find out whether tinengotinib in combination with abiraterone acetate and prednisone or enzalutamide is a safe treatment that causes few or mild side effects in people with metastatic castration-resistant prostate cancer (mCRPC).
Primary Outcome
Evaluate DLT occurrence to confirm safety and RP2D
Conditions Studied
Interventions
- DRUG Enzalutamide
- DRUG Tinengotinib
- DRUG abiraterone acetate with prednisone
Study Locations (12)
New York
- Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities) - Commack
- Memorial Sloan Kettering Westchester (Limited Protocol Activities) - Harrison
- Columbia University - New York
- Memorial Sloan Kettering Cancer Center - New York
- Memorial Sloan Kettering Nassau (Limited Protocol Activities) - Uniondale
New Jersey
- Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) - Basking Ridge
- Memorial Sloan Kettering Monmouth (Limited Protocol Activities) - Middletown
- Memorial Sloan Kettering Bergen (Limited Protocol Activities) - Montvale
Connecticut
- Yale University (Data Collection Only) - New Haven
North Carolina
- Duke University - Durham
Oregon
- Oregon Health & Science University - Portland
Pennsylvania
- Thomas Jefferson University Hospital - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2024-06-04 |
| Est. Completion | 2027-06 |
| Phase | Phase 1 |
What NCT06457919 shows while recruiting
NCT06457919 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 608-participant average among 735 other Prostate Cancer trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Prostate Cancer appearing as the primary indexed condition, and to 3 interventions - of which Enzalutamide is the first listed.
NCT06457919 lists 12 locations in 6 states (New York, New Jersey, Connecticut).
Frequently Asked Questions
What is clinical trial NCT06457919 about?
NCT06457919 is a clinical study titled "A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer". The purpose of this study is to find out whether tinengotinib in combination with abiraterone acetate and prednisone or enzalutamide is a safe treatment that causes few or mild side effects in people with metastatic castration-resistant prostate cancer (mCRPC).
What is the current status of trial NCT06457919?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 50 participants. The study started on 2024-06-04. Estimated completion is 2027-06.
What conditions does trial NCT06457919 study?
This clinical trial studies the following conditions: Prostate Cancer.
What interventions are being tested in trial NCT06457919?
The interventions under investigation include: Enzalutamide (DRUG), Tinengotinib (DRUG), abiraterone acetate with prednisone (DRUG).
Who is sponsoring clinical trial NCT06457919?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06457919 being conducted?
This trial has 12 study locations across Connecticut, New Jersey, New York, North Carolina, Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06457919's enrollment target sits among peer trials
50 469th of 735 higher than 247 of 735 other Prostate Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Prostate Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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