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Pre-IVF Treatment With a GnRH Antagonist in Women With endometriosis_temp
NCT06375811 · View on ClinicalTrials.gov ↗
Study Summary
A Phase 3 clinical trial of oral GnRH antagonist pre-treatment for women with endometriosis who are undergoing IVF, with a primary outcome of live birth rate. The investigators' central hypothesis is that in infertile woman with endometriosis undergoing in vitro fertilization-embryo transfer (IVF-ET), live birth rates will improve in those pretreated with GnRH antagonist compared to those not pretreated with GnRH antagonist.
Conditions Studied
Interventions
- DRUG Elagolix 200 MG
- OTHER Placebo or SOC IVF
Study Locations (5)
Colorado
- University of Colorado Department of Obstetrics & Gynecology — Aurora
Connecticut
- Yale School of Medicine Dept.of Ob/Gyn & Reproductive Sciences — New Haven
Illinois
- Northwestern University Department of Obstetrics and Gynecology — Chicago
Maryland
- Johns Hopkins, Division of Reproductive Science and Women's Health Research — Baltimore
North Carolina
- Duke Fertility — Morrisville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 297 participants |
| Start Date | 2024-03-16 |
| Est. Completion | 2026-09-30 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06375811
The ClinicalTrials.gov registry entry for NCT06375811 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 297 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Yale University, which has 1,283 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Infertility appearing as the primary indexed condition, and to 2 interventions — of which Elagolix 200 MG is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06375811 reports 5 study locations spanning 5 distinct geographic areas — top geographies include Colorado, Connecticut, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06375811 about?
NCT06375811 is a clinical study titled "Pre-IVF Treatment With a GnRH Antagonist in Women With endometriosis_temp". A Phase 3 clinical trial of oral GnRH antagonist pre-treatment for women with endometriosis who are undergoing IVF, with a primary outcome of live birth rate. The investigators' central hypothesis is that in infertile woman with endometriosis undergoing in vitro fertilization-embryo transfer (IVF-ET...
What is the current status of trial NCT06375811?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 297 participants. The study started on 2024-03-16. Estimated completion is 2026-09-30.
What conditions does trial NCT06375811 study?
This clinical trial studies the following conditions: Infertility, Endometriosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06375811?
The interventions under investigation include: Elagolix 200 MG (DRUG), Placebo or SOC IVF (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06375811?
This trial is sponsored by Yale University, which has 1,283 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06375811 being conducted?
This trial has 5 study locations across Colorado, Connecticut, Illinois, Maryland, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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