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COMPLETED Phase 3

Effect of Retatrutide Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1)

NCT06354660 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to investigate the efficacy and safety of retatrutide compared with placebo in participants with Type 2 Diabetes and inadequate glycemic control. The study will last about 11 months and may include up to 11 visits.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Retatrutide

Study Locations (20)

Florida

  • Northeast Research Institute (NERI) — Fleming Island
  • New Horizon Research Center — Miami
  • Ezy Medical Research — Miami
  • Clinical Research of Central Florida — Winter Haven

Arizona

  • Scottsdale Clinical Trials — Scottsdale
  • Tucson Clinical Research Institute — Tucson

California

  • San Fernando Valley Health Institute — Canoga Park
  • Ark Clinical Research — Long Beach

Pennsylvania

  • Clinical Research of Philadelphia — Philadelphia
  • Preferred Primary Care Physicians — Uniontown

Georgia

  • Trinity Research Centers — Marietta

Kansas

  • Cotton O'Neil Clinical Research Center — Topeka

Massachusetts

  • NECCR PrimaCare Research — Fall River

Missouri

  • Clinical Research Professionals — Chesterfield

Trial Details

FieldValue
Enrollment Target 537 participants
Start Date 2024-04-10
Est. Completion 2026-02-20
Phase Phase 3

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06354660

The ClinicalTrials.gov registry entry for NCT06354660 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 537 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Diabetes Type 2 appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06354660 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Florida, Arizona, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06354660 about?

NCT06354660 is a clinical study titled "Effect of Retatrutide Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1)". The purpose of this study is to investigate the efficacy and safety of retatrutide compared with placebo in participants with Type 2 Diabetes and inadequate glycemic control. The study will last about 11 months and may include up to 11 visits.

What is the current status of trial NCT06354660?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 537 participants. The study started on 2024-04-10. Estimated completion is 2026-02-20.

What conditions does trial NCT06354660 study?

This clinical trial studies the following conditions: Diabetes Type 2. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06354660?

The interventions under investigation include: Placebo (DRUG), Retatrutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06354660?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06354660 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Georgia, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial