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NCT06230159 · ClinicalTrials.gov registry record · NA
Evaluating the Impact of Synthetic Cooling Agents in Combustible Cigarettes on Smoking Perceptions and Use
A NA study, sponsored by Ohio State University Comprehensive Cancer Center.
- Completed
- Registry status
- NA
- Development phase
- 34
- Enrollment target
NCT06230159: Completed NA study, sponsored by Ohio State University Comprehensive Cancer Center.
NCT06230159 is a NA study that has completed, run by Ohio State University Comprehensive Cancer Center. The registered enrollment target is 34 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06230159, a NA study, has completed, sponsored by Ohio State University Comprehensive Cancer Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 34 participants
- Enrollment target
Study Summary
This clinical trial evaluates the impact of synthetic cooling agents in combustible cigarettes on smoking perceptions and use. Menthol, a natural chemical, is a cooling agent that increases nicotine dependence among smokers. Menthol cigarettes largely contribute to the huge burden that smoking puts on public health. Approximately 43% of adult smokers smoke menthol cigarettes. Regulatory agencies have begun a ban on menthol. In response to the ban, the tobacco industry has introduced synthetic cooling agents as a flavorless replacement to provide the same cooling effects as menthol. Information gained from this trial may help researchers determine how the addition of synthetic cooling agents changes the appeal, abuse liability potential, and respiratory toxicity profile of combustible cigarettes.
Primary Outcome
Before participant recruitment began, chemical content analysis of 3 cigarettes of each study condition was performed. We used liquid-liquid extraction (LLE) to extract nicotine, WS-3, WS-23, and menthol from cigarette samples and quantified these analytes using gas chromatography-mass spectrometry (GC-MS).
Interventions
- DIAGNOSTIC_TEST Spirometry
- BEHAVIORAL Non-menthol Cigarette Smoking
- BEHAVIORAL Menthol Cigarette Smoking
- BEHAVIORAL Synthetic Cooling Agent Cigarette Smoking
- BEHAVIORAL Usual Brand Cigarette Smoking
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2023-11-28 |
| Est. Completion | 2024-06-12 |
| Phase | NA |
What the finished NCT06230159 record still lists
NCT06230159 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 34 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 5 interventions - of which Spirometry is the first listed.
NCT06230159 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06230159 about?
NCT06230159 is a clinical study titled "Evaluating the Impact of Synthetic Cooling Agents in Combustible Cigarettes on Smoking Perceptions and Use". This clinical trial evaluates the impact of synthetic cooling agents in combustible cigarettes on smoking perceptions and use. Menthol, a natural chemical, is a cooling agent that increases nicotine dependence among smokers. Menthol cigarettes largely contribute to the huge burden that smoking puts ...
What is the current status of trial NCT06230159?
This trial is currently completed. It is a NA study. The enrollment target is 34 participants. The study started on 2023-11-28. Estimated completion is 2024-06-12.
What interventions are being tested in trial NCT06230159?
The interventions under investigation include: Spirometry (DIAGNOSTIC_TEST), Non-menthol Cigarette Smoking (BEHAVIORAL), Menthol Cigarette Smoking (BEHAVIORAL), Synthetic Cooling Agent Cigarette Smoking (BEHAVIORAL), Usual Brand Cigarette Smoking (BEHAVIORAL).
Who is sponsoring clinical trial NCT06230159?
This trial is sponsored by Ohio State University Comprehensive Cancer Center, which has 341 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06230159's enrollment target sits among peer trials
34 1570th of 2000 higher than 427 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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