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RECRUITING Phase 2

Safety and Efficacy of 3 Dose Levels of NMD670 in Adult Patients With Myasthenia Gravis

NCT06414954 · View on ClinicalTrials.gov ↗

Study Summary

This Phase 2 proof-of-concept, dose range finding study aims to evaluate the safety and efficacy of 3 dose levels of NMD670 vs placebo in adult patients with MG with antibodies against AChR or MuSK, administered twice a day (BID) for 21 days.

Interventions

  • DRUG Placebo
  • DRUG NMD670

Study Locations (20)

Other

  • UZ Leuven — Leuven
  • Aarhus University Hospital — Aarhus
  • Rigshospitalet University of Copenhagen — Copenhagen
  • Centre de référence des maladies neuromusculaires AOC-CHU de Bordeaux - Hôpital Pellegrin — Bordeaux
  • Centre de Référence des Maladies Neuromusculaires et de la SLA — Marseille
  • Centre Hospitalier Universitaire de Nantes - Hôtel Dieu Centre de Référence des Maladies Neuromusculaires Rares - — Nantes
  • CHU de Nice — Nice
  • Unité de Recherche Clinique NeuroSciences — Nice
  • JSC Curatio — Tbilisi

California

  • Profound Research LLC — Carlsbad
  • University of California Irvine Medical Center — Irvine

Florida

  • SFM Clinical Research, LLC — Boca Raton
  • Neuromuscular Research Division | University of South Florida — Tampa

Colorado

  • University of Colorado Neuromuscular Division — Aurora

Georgia

  • Augusta University, Neuroscience Center — Augusta

Missouri

  • NextGen Precision Health — Columbia

North Carolina

  • The University of North Carolina at Chapel Hill — Chapel Hill

Ohio

  • The Ohio State University — Columbus

Trial Details

FieldValue
Enrollment Target 84 participants
Start Date 2024-05-16
Est. Completion 2026-05
Phase Phase 2

Sponsor

NMD Pharma A/S

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06414954

The ClinicalTrials.gov registry entry for NCT06414954 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 84 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is NMD Pharma A/S, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Myasthenia Gravis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06414954 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Other, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06414954 about?

NCT06414954 is a clinical study titled "Safety and Efficacy of 3 Dose Levels of NMD670 in Adult Patients With Myasthenia Gravis". This Phase 2 proof-of-concept, dose range finding study aims to evaluate the safety and efficacy of 3 dose levels of NMD670 vs placebo in adult patients with MG with antibodies against AChR or MuSK, administered twice a day (BID) for 21 days.

What is the current status of trial NCT06414954?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 84 participants. The study started on 2024-05-16. Estimated completion is 2026-05.

What conditions does trial NCT06414954 study?

This clinical trial studies the following conditions: Myasthenia Gravis, Myasthenia Gravis, MuSK. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06414954?

The interventions under investigation include: Placebo (DRUG), NMD670 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06414954?

This trial is sponsored by NMD Pharma A/S, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06414954 being conducted?

This trial has 20 study locations across California, Colorado, Florida, Georgia, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial