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NCT06188923 · ClinicalTrials.gov registry record · Phase 2
A New Intervention to Improve Function in Veterans With Anxiety and Depression
A Phase 2 study of Anxiety and Depression, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 84
- Enrollment target
- 1
- Study location
NCT06188923 is a Phase 2 study of Anxiety and Depression that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 84 participants. The trial reports 1 study location across 1 state.
The verdict
NCT06188923, a Phase 2 study of Anxiety and Depression, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 84 participants
- Enrollment target
- 1
- Study location
Study Summary
Anxiety and depression symptoms occur at high rates in Veteran populations and can significantly impact function, compromising the ability to work and to successfully form and maintain valued relationships. Several other symptoms commonly occur with anxiety and depression, including poor sleep quality and chronic pain. Since all these symptoms frequently occur together, they may have a common underlying biological basis. A single medication that could effectively treat all these symptoms would be ideal. Converging data suggest that pregnenolone is a promising pharmacological agent for treating multiple psychiatric symptoms and functional impairment. The investigators thus propose to conduct a clinical trial of pregnenolone in Veterans with anxiety and depression symptoms. Pregnenolone has minimal side effects, and the prior research demonstrates that pregnenolone is well-tolerated by Veterans. Treatment with pregnenolone could thus be an efficacious new therapeutic for Veterans experiencing depression, anxiety, poor sleep quality and chronic pain conditions.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Pregnenolone
Study Locations (1)
North Carolina
- Durham VA Medical Center, Durham, NC - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 84 participants |
| Start Date | 2025-08-14 |
| Est. Completion | 2028-09-30 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06188923
The ClinicalTrials.gov registry entry for NCT06188923 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 84 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is VA Office of Research and Development, which has 1,668 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Anxiety and Depression appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06188923 reports 1 study location spanning 1 distinct geographic area - top geographies include North Carolina.
Frequently Asked Questions
What is clinical trial NCT06188923 about?
NCT06188923 is a clinical study titled "A New Intervention to Improve Function in Veterans With Anxiety and Depression". Anxiety and depression symptoms occur at high rates in Veteran populations and can significantly impact function, compromising the ability to work and to successfully form and maintain valued relationships. Several other symptoms commonly occur with anxiety and depression, including poor sleep quali...
What is the current status of trial NCT06188923?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 84 participants. The study started on 2025-08-14. Estimated completion is 2028-09-30.
What conditions does trial NCT06188923 study?
This clinical trial studies the following conditions: Anxiety and Depression.
What interventions are being tested in trial NCT06188923?
The interventions under investigation include: Placebo (DRUG), Pregnenolone (DRUG).
Who is sponsoring clinical trial NCT06188923?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06188923 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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