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NCT06135870 · ClinicalTrials.gov registry record
Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study)
A clinical trial of Leiomyoma and Fibroid, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- 150
- Enrollment target
- 1
- Study location
NCT06135870: Recruiting study of Leiomyoma and Fibroid, sponsored by Johns Hopkins University.
NCT06135870 is a study of Leiomyoma and Fibroid that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 150 participants, above the 87-participant average among 8 other Leiomyoma trials with a reported enrollment target (72% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06135870, a study of Leiomyoma and Fibroid, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators are evaluating the role of senescent cells in uterine fibroids.
Primary Outcome
Perform scRNASeq on human fibroids and control myometrium tissue and apply transfer learning algorithm for SnC identification and phenotyping to identify cell-cell communication patterns in fibroids versus control myometrial tissue using Domino to validate computationally predicted senescent cell types. The computationally predicted immune phenotypes will be validated with flow cytometry.
Study Locations (1)
Maryland
- Johns Hopkins Hospital - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2023-11-01 |
| Est. Completion | 2027-12-31 |
What NCT06135870 shows while recruiting
NCT06135870 is an observational study that tracks outcomes without assigning an intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, above the 87-participant average among 8 other Leiomyoma trials with a reported enrollment target (72% higher).
The record links to 2 conditions, with Leiomyoma appearing as the primary indexed condition, and to 0 interventions.
NCT06135870 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT06135870 about?
NCT06135870 is a clinical study titled "Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study)". The investigators are evaluating the role of senescent cells in uterine fibroids.
What is the current status of trial NCT06135870?
This trial is currently recruiting. The enrollment target is 150 participants. The study started on 2023-11-01. Estimated completion is 2027-12-31.
What conditions does trial NCT06135870 study?
This clinical trial studies the following conditions: Leiomyoma, Fibroid.
Who is sponsoring clinical trial NCT06135870?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06135870 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Leiomyoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06135870's enrollment target sits among peer trials
150 2nd of 8 the highest of 8 other Leiomyoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Leiomyoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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