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NCT06143631 · ClinicalTrials.gov registry record · Phase 4
Prescription of Letrozole for Uterine Myoma
A Phase 4 study of Leiomyoma and Fibroid Uterus, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 140
- Enrollment target
- 5
- Study locations
NCT06143631: Recruiting Phase 4 study of Leiomyoma and Fibroid Uterus, sponsored by University of California, San Francisco.
NCT06143631 is a Phase 4 study of Leiomyoma and Fibroid Uterus that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 140 participants, above the 88-participant average among 8 other Leiomyoma trials with a reported enrollment target (59% higher). The trial reports 5 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06143631, a Phase 4 study of Leiomyoma and Fibroid Uterus, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 140 participants
- Enrollment target
- 5
- Study locations
Study Summary
The PLUM Study is a randomized, double-blinded, 2-arm, parallel-group, placebo-controlled trial is designed to compare the efficacy of letrozole versus placebo on leiomyoma-related symptoms and quality of life as well as leiomyoma and uterine size.
Primary Outcome
Change in Uterine Fibroid Symptoms Quality of Life (UFS-QOL) Symptom Severity Scale (SSS) score \[Range 8-40 with higher score indicating worse symptoms and worse outcomes\]
Conditions Studied
Interventions
- OTHER Placebo
- DRUG Letrozole 2.5mg
Study Locations (5)
California
- University of California, Los Angeles - Los Angeles
- University of California, San Francisco - San Francisco
Minnesota
- Mayo Clinic - Rochester
Mississippi
- University of Mississippi Medical Center - Jackson
North Carolina
- Duke University - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 140 participants |
| Start Date | 2024-07-24 |
| Est. Completion | 2027-04-30 |
| Phase | Phase 4 |
What NCT06143631 shows while recruiting
NCT06143631 is an interventional study that assigns participants to a tested intervention. The registered 140 participants enrollment target is mid-sized for trials with a published cap, above the 88-participant average among 8 other Leiomyoma trials with a reported enrollment target (59% higher).
The record links to 4 conditions, with Leiomyoma appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06143631 lists 5 locations in 4 states (California, Minnesota, Mississippi).
Frequently Asked Questions
What is clinical trial NCT06143631 about?
NCT06143631 is a clinical study titled "Prescription of Letrozole for Uterine Myoma". The PLUM Study is a randomized, double-blinded, 2-arm, parallel-group, placebo-controlled trial is designed to compare the efficacy of letrozole versus placebo on leiomyoma-related symptoms and quality of life as well as leiomyoma and uterine size.
What is the current status of trial NCT06143631?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 140 participants. The study started on 2024-07-24. Estimated completion is 2027-04-30.
What conditions does trial NCT06143631 study?
This clinical trial studies the following conditions: Leiomyoma, Fibroid Uterus, Leiomyoma, Uterine, Fibroid.
What interventions are being tested in trial NCT06143631?
The interventions under investigation include: Placebo (OTHER), Letrozole 2.5mg (DRUG).
Who is sponsoring clinical trial NCT06143631?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06143631 being conducted?
This trial has 5 study locations across California, Minnesota, Mississippi, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Leiomyoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06143631's enrollment target sits among peer trials
140 3rd of 8 higher than 6 of 8 other Leiomyoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Leiomyoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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