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NCT06104735 · ClinicalTrials.gov registry record · NA
Finding the Best Combination of Brain and Spinal Cord Stimulation With Hand Training After Spinal Cord Injury
A NA study of Spinal Cord Injuries, sponsored by Bronx VA Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 12
- Enrollment target
- 1
- Study location
NCT06104735: Recruiting NA study of Spinal Cord Injuries, sponsored by Bronx VA Medical Center.
NCT06104735 is a NA study of Spinal Cord Injuries that is actively recruiting participants, run by Bronx VA Medical Center. The registered enrollment target is 12 participants, below the 62-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06104735, a NA study of Spinal Cord Injuries, is actively recruiting participants, sponsored by Bronx VA Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
While physical exercise remains the foundation for any rehabilitation therapy, the team seeks to improve the benefits of exercise by combining it with the concept of "Fire Together, Wire Together" - when brain stimulation is synchronized with spinal cord stimulation, nerve circuits in the spinal cord strengthen - a phenomenon termed "Spinal Cord Associative Plasticity", or SCAP. This project will build on the team's promising preliminary findings. When one pulse of brain stimulation is synchronized with one pulse of cervical spinal stimulation, hand muscle responses are larger than with brain stimulation alone or unsynchronized stimulation. However, the team does not know the best ways to apply SCAP repetitively, especially in conjunction with exercise, to increase and extend improvements in clinical function. Do ideal intervention parameters vary across individuals, or do they need to be customized? The team will take a systematic approach with people who have chronic cervical SCI to determine each person's best combination of SCAP with task-oriented hand exercise. Participants will undergo up to 53 intervention, verification, and follow-up sessions over a period of 6 to 10 months each. The team will measure clinical and physiological responses of hand and arm muscles to each intervention. Regaining control over hand function represents the top priority for individuals with cervical SCI. Furthermore, this approach could be compatible with other future interventions, including medications and cell-based treatments.
Primary Outcome
The primary neurophysiological outcome will be corticospinal excitability measured at the target muscle. The target muscle will be determined during the first evaluation session, with preference for first dorsal interosseous (FDI), abductor pollicis brevis (APB), or extensor carpi radialis (ECR) muscles based on muscle excitability and consistency. TMS recruitment curves will be collected. The amplitude of target muscle responses to TMS and spinal cord stimulation will be compared after the vari
Conditions Studied
Interventions
- PROCEDURE Exercise
- PROCEDURE Synaptic Pairing Interval
- PROCEDURE Frequency
- PROCEDURE Bouts
- PROCEDURE Spacing
Study Locations (1)
New York
- James J. Peters VA Medical Center, Bronx, NY - The Bronx
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2024-05-24 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What NCT06104735 shows while recruiting
NCT06104735 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 62-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (81% lower).
The record links to 1 condition, with Spinal Cord Injuries appearing as the primary indexed condition, and to 5 interventions - of which Exercise is the first listed.
NCT06104735 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT06104735 about?
NCT06104735 is a clinical study titled "Finding the Best Combination of Brain and Spinal Cord Stimulation With Hand Training After Spinal Cord Injury". While physical exercise remains the foundation for any rehabilitation therapy, the team seeks to improve the benefits of exercise by combining it with the concept of "Fire Together, Wire Together" - when brain stimulation is synchronized with spinal cord stimulation, nerve circuits in the spinal cor...
What is the current status of trial NCT06104735?
This trial is currently recruiting. It is a NA study. The enrollment target is 12 participants. The study started on 2024-05-24. Estimated completion is 2026-12-31.
What conditions does trial NCT06104735 study?
This clinical trial studies the following conditions: Spinal Cord Injuries.
What interventions are being tested in trial NCT06104735?
The interventions under investigation include: Exercise (PROCEDURE), Synaptic Pairing Interval (PROCEDURE), Frequency (PROCEDURE), Bouts (PROCEDURE), Spacing (PROCEDURE).
Who is sponsoring clinical trial NCT06104735?
This trial is sponsored by Bronx VA Medical Center, which has 13 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06104735 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Spinal Cord Injuries
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06104735's enrollment target sits among peer trials
12 165th of 202 higher than 30 of 202 other Spinal Cord Injuries trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Cord Injuries trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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