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NCT06066723 · ClinicalTrials.gov registry record
19F MRI in Healthy Children and Children With Mild Cystic Fibrosis Lung Disease
A clinical trial of Cystic Fibrosis in Children, sponsored by University of North Carolina, Chapel Hill.
- Recruiting
- Registry status
- 15
- Enrollment target
- 1
- Study location
NCT06066723 is a study of Cystic Fibrosis in Children that is actively recruiting participants, run by University of North Carolina, Chapel Hill. The registered enrollment target is 15 participants, below the 88-participant average among 6 other Cystic Fibrosis in Children trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06066723, a study of Cystic Fibrosis in Children, is actively recruiting participants, sponsored by University of North Carolina, Chapel Hill.
- RECRUITING
- Registry status
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
This study capitalizes on the emerging technology of 19F MRI, using conventional 'thermally' polarized perfluorinated gas (perfluoropropane, or PFP) mixed with oxygen and studied with magnetic resonance imaging (MRI) to visualize ventilation. This technique has not been studied in children. Children and adolescents (6-17 years old) with cystic fibrosis (CF) who have normal spirometry will undergo 19F MRI with the inhalation of an inert contrast gas to study ventilation. Comparisons will be made to a cohort of healthy children (6-17 years old) who will perform the same measures. The primary outcome measure is the feasibility of conducting these studies in the pediatric population. Parallel performance of multiple breath nitrogen washout (MBW) and spirometry will be used to compare the sensitivity of these outcomes to the presence of mild lung disease in these children. Finally, the investigators will compare data obtained during standard breath holds with a novel "free-breathing" technique that will eliminate the need for breath holds during MRI acquisition.
Conditions Studied
Interventions
- COMBINATION_PRODUCT 19F MRI
Study Locations (1)
North Carolina
- University of North Carolina at Chapel Hill - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2025-06-16 |
| Est. Completion | 2026-06 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06066723
The ClinicalTrials.gov registry entry for NCT06066723 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 88-participant average among 6 other Cystic Fibrosis in Children trials with a reported enrollment target (83% lower). The listed sponsor is University of North Carolina, Chapel Hill, which has 1,109 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Cystic Fibrosis in Children appearing as the primary indexed condition, and to 1 intervention - of which 19F MRI is the first listed.
NCT06066723 reports 1 study location spanning 1 distinct geographic area - top geographies include North Carolina.
Frequently Asked Questions
What is clinical trial NCT06066723 about?
NCT06066723 is a clinical study titled "19F MRI in Healthy Children and Children With Mild Cystic Fibrosis Lung Disease". This study capitalizes on the emerging technology of 19F MRI, using conventional 'thermally' polarized perfluorinated gas (perfluoropropane, or PFP) mixed with oxygen and studied with magnetic resonance imaging (MRI) to visualize ventilation. This technique has not been studied in children. Childre...
What is the current status of trial NCT06066723?
This trial is currently recruiting. The enrollment target is 15 participants. The study started on 2025-06-16. Estimated completion is 2026-06.
What conditions does trial NCT06066723 study?
This clinical trial studies the following conditions: Cystic Fibrosis in Children.
What interventions are being tested in trial NCT06066723?
The interventions under investigation include: 19F MRI (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT06066723?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06066723 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Read our methodology - how this data is sourced, computed, and verified.
Related
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