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NCT05995223 · ClinicalTrials.gov registry record · NA
Oxygen Uptake Kinetics During Submaximal Exercise in Adults With Down Syndrome
A NA study of Down Syndrome, sponsored by University of Nevada, Las Vegas.
- Completed
- Registry status
- NA
- Development phase
- 28
- Enrollment target
- 1
- Study location
NCT05995223: Completed NA study of Down Syndrome, sponsored by University of Nevada, Las Vegas.
NCT05995223 is a NA study of Down Syndrome that has completed, run by University of Nevada, Las Vegas. The registered enrollment target is 28 participants, below the 2,471-participant average among 54 other Down Syndrome trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05995223, a NA study of Down Syndrome, has completed, sponsored by University of Nevada, Las Vegas.
- COMPLETED
- Registry status
- NA
- Development phase
- 28 participants
- Enrollment target
- 1
- Study location
Study Summary
This study aims to compare the rate at which oxygen uptake adapts to submaximal, moderate intensity exercise (oxygen uptake kinetics) between adults with and without Down syndrome, to determine the contribution of oxygen uptake kinetics to exercise intolerance of adults with Down syndrome. Additionally, the study will investigate the role of oxygen delivery (by the cardiovascular circuit) and oxygen utilization (in the mitochondria) on the oxygen uptake kinetics of adults with Down syndrome to identify specific areas which adults with Down syndrome could benefit from targeting during exercise training. Overall, this study aims to contribute to the knowledge on the exercise capacity of adults with Down syndrome, in order to improve the way adults with Down syndrome participate in and benefit from exercise. Participants will perform a maximal exercise test on a treadmill, and walk on a treadmill at a submaximal, moderate intensity speed and incline, during which oxygen uptake at the lungs, cardiac output, and oxygen utilization in the muscle will be measured.
Primary Outcome
The finite rate at which oxygen uptake (measured with breath-by-breath gas exchange analysis at the mouth) adapts to a (submaximal) increase in exercise intensity, primarily captured by time constant tau, which describes the time needed to reach 63% of the required, steady state oxygen uptake
Conditions Studied
Interventions
- OTHER Submaximal exercise protocol
Study Locations (1)
Nevada
- University of Nevada, Las Vegas - Las Vegas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2023-10-04 |
| Est. Completion | 2024-06-27 |
| Phase | NA |
What the finished NCT05995223 record still lists
NCT05995223 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 28 participants, a relatively small participant target, below the 2,471-participant average among 54 other Down Syndrome trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Down Syndrome appearing as the primary indexed condition, and to 1 intervention - of which Submaximal exercise protocol is the first listed.
NCT05995223 reports a single indexed study location in Nevada.
Frequently Asked Questions
What is clinical trial NCT05995223 about?
NCT05995223 is a clinical study titled "Oxygen Uptake Kinetics During Submaximal Exercise in Adults With Down Syndrome". This study aims to compare the rate at which oxygen uptake adapts to submaximal, moderate intensity exercise (oxygen uptake kinetics) between adults with and without Down syndrome, to determine the contribution of oxygen uptake kinetics to exercise intolerance of adults with Down syndrome. Additiona...
What is the current status of trial NCT05995223?
This trial is currently completed. It is a NA study. The enrollment target is 28 participants. The study started on 2023-10-04. Estimated completion is 2024-06-27.
What conditions does trial NCT05995223 study?
This clinical trial studies the following conditions: Down Syndrome.
What interventions are being tested in trial NCT05995223?
The interventions under investigation include: Submaximal exercise protocol (OTHER).
Who is sponsoring clinical trial NCT05995223?
This trial is sponsored by University of Nevada, Las Vegas, which has 52 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05995223 being conducted?
This trial has 1 study location across Nevada. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05995223's enrollment target sits among peer trials
28 42nd of 54 higher than 13 of 54 other Down Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Down Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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