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NCT05900401 · ClinicalTrials.gov registry record · Phase 1

Delayed Tolerance Through Mixed Chimerism

A Phase 1 study of Kidney Transplant; Complications and Kidney Failure, sponsored by Massachusetts General Hospital.

Active
Registry status
Phase 1
Development phase
20
Enrollment target
1
Study location

NCT05900401 is a Phase 1 study of Kidney Transplant; Complications and Kidney Failure that is active but no longer recruiting, run by Massachusetts General Hospital. The registered enrollment target is 20 participants, below the 121-participant average among 19 other Kidney Transplant; Complications trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05900401, a Phase 1 study of Kidney Transplant; Complications and Kidney Failure, is active but no longer recruiting, sponsored by Massachusetts General Hospital.

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
20 participants
Enrollment target
1
Study location

Study Summary

This study will examine the safety and effectiveness of a bone marrow transplant after kidney transplant (from either a living or deceased donor). An investigational medication and other treatments will be given prior to and after the transplant to help protect the transplanted kidney from being attacked by the body's immune system

Conditions Studied

Kidney Transplant; Complications Kidney Failure Chimera

Interventions

  • DRUG Cyclophosphamide
  • DRUG Fludarabine
  • DRUG Rituximab
  • OTHER Bone Marrow Transplant
  • PROCEDURE Peripheral Blood Stem Cell Collection

Study Locations (1)

Massachusetts

  • Massachusetts General Hospital - Boston

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 2023-10-01
Est. Completion 2030-12
Phase Phase 1

Sponsor

Massachusetts General Hospital

2,032 total trials

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What the Registry Record Tells You About NCT05900401

The ClinicalTrials.gov registry entry for NCT05900401 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 121-participant average among 19 other Kidney Transplant; Complications trials with a reported enrollment target (83% lower). The listed sponsor is Massachusetts General Hospital, which has 2,032 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Kidney Transplant; Complications appearing as the primary indexed condition, and to 5 interventions - of which Cyclophosphamide is the first listed.

NCT05900401 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.

Frequently Asked Questions

What is clinical trial NCT05900401 about?

NCT05900401 is a clinical study titled "Delayed Tolerance Through Mixed Chimerism". This study will examine the safety and effectiveness of a bone marrow transplant after kidney transplant (from either a living or deceased donor). An investigational medication and other treatments will be given prior to and after the transplant to help protect the transplanted kidney from being att...

What is the current status of trial NCT05900401?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2023-10-01. Estimated completion is 2030-12.

What conditions does trial NCT05900401 study?

This clinical trial studies the following conditions: Kidney Transplant; Complications, Kidney Failure, Chimera.

What interventions are being tested in trial NCT05900401?

The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), Rituximab (DRUG), Bone Marrow Transplant (OTHER), Peripheral Blood Stem Cell Collection (PROCEDURE).

Who is sponsoring clinical trial NCT05900401?

This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05900401 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.