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NCT05900401 · ClinicalTrials.gov registry record · Phase 1
Delayed Tolerance Through Mixed Chimerism
A Phase 1 study of Kidney Transplant; Complications and Kidney Failure, sponsored by Massachusetts General Hospital.
- Active
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT05900401: Active Phase 1 study of Kidney Transplant; Complications and Kidney Failure, sponsored by Massachusetts General Hospital.
NCT05900401 is a Phase 1 study of Kidney Transplant; Complications and Kidney Failure that is active but no longer recruiting, run by Massachusetts General Hospital. The registered enrollment target is 20 participants, below the 121-participant average among 19 other Kidney Transplant; Complications trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05900401, a Phase 1 study of Kidney Transplant; Complications and Kidney Failure, is active but no longer recruiting, sponsored by Massachusetts General Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will examine the safety and effectiveness of a bone marrow transplant after kidney transplant (from either a living or deceased donor). An investigational medication and other treatments will be given prior to and after the transplant to help protect the transplanted kidney from being attacked by the body's immune system
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Fludarabine
- DRUG Rituximab
- OTHER Bone Marrow Transplant
- PROCEDURE Peripheral Blood Stem Cell Collection
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2023-10-01 |
| Est. Completion | 2030-12 |
| Phase | Phase 1 |
What the registry record for NCT05900401 still lists
NCT05900401 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 121-participant average among 19 other Kidney Transplant; Complications trials with a reported enrollment target (83% lower).
The record links to 3 conditions, with Kidney Transplant; Complications appearing as the primary indexed condition, and to 5 interventions - of which Cyclophosphamide is the first listed.
NCT05900401 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05900401 about?
NCT05900401 is a clinical study titled "Delayed Tolerance Through Mixed Chimerism". This study will examine the safety and effectiveness of a bone marrow transplant after kidney transplant (from either a living or deceased donor). An investigational medication and other treatments will be given prior to and after the transplant to help protect the transplanted kidney from being att...
What is the current status of trial NCT05900401?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2023-10-01. Estimated completion is 2030-12.
What conditions does trial NCT05900401 study?
This clinical trial studies the following conditions: Kidney Transplant; Complications, Kidney Failure, Chimera.
What interventions are being tested in trial NCT05900401?
The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), Rituximab (DRUG), Bone Marrow Transplant (OTHER), Peripheral Blood Stem Cell Collection (PROCEDURE).
Who is sponsoring clinical trial NCT05900401?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05900401 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Kidney Transplant; Complications
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05900401's enrollment target sits among peer trials
20 18th of 19 higher than 1 of 19 other Kidney Transplant; Complications trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Kidney Transplant; Complications trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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