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NCT05785871 · ClinicalTrials.gov registry record
Hypertension, Brain Clearance, and Markers of Neurodegeneration
A clinical trial, sponsored by Weill Medical College of Cornell University.
- Completed
- Registry status
- 80
- Enrollment target
NCT05785871: Completed study, sponsored by Weill Medical College of Cornell University.
NCT05785871 is a clinical trial that has completed, run by Weill Medical College of Cornell University. The registered enrollment target is 80 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05785871 has completed, sponsored by Weill Medical College of Cornell University.
- COMPLETED
- Registry status
- 80 participants
- Enrollment target
Study Summary
The purpose of this research study is to measure cerebrospinal fluid (CSF) clearance in subjects with and without high blood pressure. CSF cushions the brain from impact and carries waste products from the brain to the bloodstream. This process is known as clearance. Impaired removal of proteins from the aging brain causes their buildup and may contribute to an increased risk for Alzheimer's disease. It is also suspected that clearance may be related to the health of vessels carrying the blood throughout the brain. It is known that high blood pressure damages blood vessels and thus may impair clearance. In this project we will examine if having high blood pressure is related to impaired brain clearance and whether treating high blood pressure improves clearance and reduces buildup of Alzheimer's disease-related proteins. Participants will be asked to undergo a medical examination, testing of memory, brain imaging (both magnetic resonance and positron emission tomography, and spinal tap at the beginning of the study and 1 -2 years later.
Primary Outcome
cerebral blood flow with arterial spin labeling MRI
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2020-11-18 |
| Est. Completion | 2025-06-30 |
What the finished NCT05785871 record still lists
NCT05785871 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 80 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT05785871 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05785871 about?
NCT05785871 is a clinical study titled "Hypertension, Brain Clearance, and Markers of Neurodegeneration". The purpose of this research study is to measure cerebrospinal fluid (CSF) clearance in subjects with and without high blood pressure. CSF cushions the brain from impact and carries waste products from the brain to the bloodstream. This process is known as clearance. Impaired removal of proteins fro...
What is the current status of trial NCT05785871?
This trial is currently completed. The enrollment target is 80 participants. The study started on 2020-11-18. Estimated completion is 2025-06-30.
Who is sponsoring clinical trial NCT05785871?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
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