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NCT05775289 · ClinicalTrials.gov registry record · Phase 2
A Study of Tobemstomig Plus Platinum-Based Chemotherapy vs Pembrolizumab Plus Platinum-Based Chemotherapy in Participants With Previously Untreated Non-Small Cell Lung Cancer
A Phase 2 study of Non-Small Cell Lung Cancer, sponsored by Hoffmann-La Roche.
- Active
- Registry status
- Phase 2
- Development phase
- 182
- Enrollment target
- 20
- Study locations
NCT05775289: Active Phase 2 study of Non-Small Cell Lung Cancer, sponsored by Hoffmann-La Roche.
NCT05775289 is a Phase 2 study of Non-Small Cell Lung Cancer that is active but no longer recruiting, run by Hoffmann-La Roche. The registered enrollment target is 182 participants, below the 652-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (72% lower). The trial reports 20 study locations across 10 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05775289, a Phase 2 study of Non-Small Cell Lung Cancer, is active but no longer recruiting, sponsored by Hoffmann-La Roche.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 182 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tobemstomig (RO7247669) in combination with platinum-based chemotherapy compared with pembrolizumab plus platinum-based chemotherapy in participants with previously untreated, locally advanced, unresectable (Stage IIIB/IIIC) or metastatic (Stage IV) non-small-cell lung cancer (NSCLC) who are not eligible to receive curative surgery and/or definitive chemoradiotherapy.
Primary Outcome
PFS is defined as the time from randomization to the first occurrence of disease progression or death from any cause (whichever occurs first), as determined by the investigator according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Carboplatin
- DRUG Pemetrexed
- DRUG Paclitaxel
- DRUG Tobemstomig
Study Locations (20)
Other
- UZ Brussel - Brussels
- Jessa Zkh (Campus Virga Jesse) - Hasselt
- UZ Leuven Gasthuisberg - Leuven
- AZ St Maarten Campus Leopoldstr - Mechelen
- Centre Leon Berard - Lyon
- Hopital Cochin - Paris
- Ico Rene Gauducheau - Saint-Herblain
- CHU de Toulouse - Hôpital Larrey - Toulouse
Victoria
- Barwon Health - Geelong
- Monash Health - Melbourne
Rio Grande do Sul
- Hospital Nossa Senhora da Conceicao - Porto Alegre
- Hospital de Clínicas de Porto Alegre X - Porto Alegre
São Paulo
- Hospital de Cancer de Barretos - Barretos
- Instituto do Cancer do Estado de Sao Paulo - ICESP - São Paulo
Michigan
- Henry Ford Health System - Detroit
Nevada
- Renown Regional Medical Center Hospital - Reno
New South Wales
- Westmead Hospital - Westmead
South Australia
- Lyell McEwin Hospital - Adelaide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 182 participants |
| Start Date | 2023-03-15 |
| Est. Completion | 2026-06-01 |
| Phase | Phase 2 |
What the registry record for NCT05775289 still lists
NCT05775289 is an interventional study that assigns participants to a tested intervention. The registered 182 participants enrollment target is mid-sized for trials with a published cap, below the 652-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (72% lower).
The record links to 1 condition, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions - of which Pembrolizumab is the first listed.
NCT05775289 names 20 study sites across 10 states, led by Other, Victoria, Rio Grande do Sul.
Frequently Asked Questions
What is clinical trial NCT05775289 about?
NCT05775289 is a clinical study titled "A Study of Tobemstomig Plus Platinum-Based Chemotherapy vs Pembrolizumab Plus Platinum-Based Chemotherapy in Participants With Previously Untreated Non-Small Cell Lung Cancer". The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tobemstomig (RO7247669) in combination with platinum-based chemotherapy compared with pembrolizumab plus platinum-based chemotherapy in participants with previously untreated, locally advanced, unresectable (Stage...
What is the current status of trial NCT05775289?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 182 participants. The study started on 2023-03-15. Estimated completion is 2026-06-01.
What conditions does trial NCT05775289 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer.
What interventions are being tested in trial NCT05775289?
The interventions under investigation include: Pembrolizumab (DRUG), Carboplatin (DRUG), Pemetrexed (DRUG), Paclitaxel (DRUG), Tobemstomig (DRUG).
Who is sponsoring clinical trial NCT05775289?
This trial is sponsored by Hoffmann-La Roche, which has 909 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05775289 being conducted?
This trial has 20 study locations across Michigan, Nevada, New South Wales, South Australia, Victoria. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05775289's enrollment target sits among peer trials
182 174th of 454 higher than 281 of 454 other Non-Small Cell Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Non-Small Cell Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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