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NCT05764772 · ClinicalTrials.gov registry record
CT Evaluation of Carotid Plaque Components
A clinical trial of Carotid Plaque, sponsored by University of Pennsylvania.
- Recruiting
- Registry status
- 70
- Enrollment target
- 1
- Study location
NCT05764772: Recruiting study of Carotid Plaque, sponsored by University of Pennsylvania.
NCT05764772 is a study of Carotid Plaque that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 70 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05764772, a study of Carotid Plaque, is actively recruiting participants, sponsored by University of Pennsylvania.
- RECRUITING
- Registry status
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this observational study is to validate the diagnostic performance of photon counting/spectral CT to distinguish tissue components in ischemic stroke with MRI, semi-automated segmentation software or histology as the reference standard. The main question\[s\] it aims to answer are: 1. Presence or absence of calcium, hemorrhage, and lipid plaque components as determined on CT will be confirmed with carotid MRI, segmentation quantitative (e.g., volume) output from segmentation software, or histologic staining. 2. Volumes of hemorrhage, lipid, and calcium components will be measured to determine plaque phenotype and correlated with ipsilateral intracranial stroke burden. Participants will be asked to do the following: Aim 1: * 1 Photon counting/spectral CT angiography of the neck * 1 Research Carotid/Neck MRI of the carotid arteries (if eligible) Aim 2: * 1 Research Carotid/Neck MRI of the carotid arteries (if eligible) * 1 Photon counting/spectral CT angiography of the neck * 1 Carotid plaque tissue from participants surgery will be retrieved, imaged, and stained (if eligible)
Primary Outcome
Presence or absence of calcium, hemorrhage, and lipid plaque components as determined on CT will be confirmed with carotid MRI, segmentation quantitative (e.g., volume) output from segmentation software, or histologic staining.
Conditions Studied
Study Locations (1)
Pennsylvania
- University of Pennsylvania Hospital - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2023-10-01 |
| Est. Completion | 2028-12 |
What NCT05764772 shows while recruiting
NCT05764772 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 70 participants, a relatively small participant target.
The record links to 1 condition, with Carotid Plaque appearing as the primary indexed condition, and to 0 interventions.
NCT05764772 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05764772 about?
NCT05764772 is a clinical study titled "CT Evaluation of Carotid Plaque Components". The goal of this observational study is to validate the diagnostic performance of photon counting/spectral CT to distinguish tissue components in ischemic stroke with MRI, semi-automated segmentation software or histology as the reference standard. The main question\[s\] it aims to answer are: 1. ...
What is the current status of trial NCT05764772?
This trial is currently recruiting. The enrollment target is 70 participants. The study started on 2023-10-01. Estimated completion is 2028-12.
What conditions does trial NCT05764772 study?
This clinical trial studies the following conditions: Carotid Plaque.
Who is sponsoring clinical trial NCT05764772?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05764772 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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