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NCT05721781 · ClinicalTrials.gov registry record · NA
Reducing Risk for Infective Endocarditis
A NA study of Bacteremia and Infective Endocarditis, sponsored by Wake Forest University Health Sciences.
- Recruiting
- Registry status
- NA
- Development phase
- 320
- Enrollment target
- 6
- Study locations
NCT05721781: Recruiting NA study of Bacteremia and Infective Endocarditis, sponsored by Wake Forest University Health Sciences.
NCT05721781 is a NA study of Bacteremia and Infective Endocarditis that is actively recruiting participants, run by Wake Forest University Health Sciences. The registered enrollment target is 320 participants, below the 7,548-participant average among 11 other Bacteremia trials with a reported enrollment target (96% lower). The trial reports 6 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05721781, a NA study of Bacteremia and Infective Endocarditis, is actively recruiting participants, sponsored by Wake Forest University Health Sciences.
- RECRUITING
- Registry status
- NA
- Development phase
- 320 participants
- Enrollment target
- 6
- Study locations
Study Summary
This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth. One group of participants will have a dental cleaning and oral health instructions and the other group of participants will not. Researchers will compare the blood test results from the two groups to see if the education made a difference in preventing bacteria and how long it stays in the bloodstream.
Primary Outcome
Blood samples are assessed for positivity of Infective Endocarditis (IE) causing oral species. A participant is defined as having bacteremia at a visit if that participant has at least one blood draw positive for bacteremia of IE-causing species during or after tooth brushing, provided that those IE-causing species were not present at the pre-brushing blood draw.
Conditions Studied
Interventions
- BEHAVIORAL Oral Hygiene instruction
- PROCEDURE Dental Cleaning
Study Locations (6)
New York
- New York University - New York
- University of Rochester Medical Center - Rochester
Massachusetts
- Tufts University School of Dental Medicine and Tufts University Health Sciences Campus - Boston
Michigan
- University of Michigan School of Dentistry and Michigan Medicine - Ann Arbor
New Jersey
- Rutgers School of Dental Medicine - Newark
North Carolina
- Atrium Health's Carolinas Medical Center - Charlotte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 320 participants |
| Start Date | 2023-08-31 |
| Est. Completion | 2027-09 |
| Phase | NA |
What NCT05721781 shows while recruiting
NCT05721781 is an interventional study that assigns participants to a tested intervention. The registered 320 participants enrollment target is mid-sized for trials with a published cap, below the 7,548-participant average among 11 other Bacteremia trials with a reported enrollment target (96% lower).
The record links to 2 conditions, with Bacteremia appearing as the primary indexed condition, and to 2 interventions - of which Oral Hygiene instruction is the first listed.
NCT05721781 lists 6 locations in 5 states (New York, Massachusetts, Michigan).
Frequently Asked Questions
What is clinical trial NCT05721781 about?
NCT05721781 is a clinical study titled "Reducing Risk for Infective Endocarditis". This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth. One group of participants will have a dental cleaning and oral health instructions and...
What is the current status of trial NCT05721781?
This trial is currently recruiting. It is a NA study. The enrollment target is 320 participants. The study started on 2023-08-31. Estimated completion is 2027-09.
What conditions does trial NCT05721781 study?
This clinical trial studies the following conditions: Bacteremia, Infective Endocarditis.
What interventions are being tested in trial NCT05721781?
The interventions under investigation include: Oral Hygiene instruction (BEHAVIORAL), Dental Cleaning (PROCEDURE).
Who is sponsoring clinical trial NCT05721781?
This trial is sponsored by Wake Forest University Health Sciences, which has 1,140 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05721781 being conducted?
This trial has 6 study locations across Massachusetts, Michigan, New Jersey, New York, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05721781's enrollment target sits among peer trials
320 8th of 11 higher than 4 of 11 other Bacteremia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Bacteremia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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