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NCT05709483 · ClinicalTrials.gov registry record · Early Phase 1
Predictors of Aspirin Failure in Preeclampsia Prevention
A Early Phase 1 study of Preeclampsia, sponsored by Rockefeller University.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 130
- Enrollment target
- 1
- Study location
NCT05709483: Recruiting Early Phase 1 study of Preeclampsia, sponsored by Rockefeller University.
NCT05709483 is a Early Phase 1 study of Preeclampsia that is actively recruiting participants, run by Rockefeller University. The registered enrollment target is 130 participants, below the 1,123-participant average among 48 other Preeclampsia trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05709483, a Early Phase 1 study of Preeclampsia, is actively recruiting participants, sponsored by Rockefeller University.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 130 participants
- Enrollment target
- 1
- Study location
Study Summary
Hypertensive disorders of pregnancy (including preeclampsia) are among the leading causes of pregnancy complications and maternal deaths worldwide. They also increase the risks to the babies. Numerous interventions have been suggested in order to reduce the rate of preeclampsia. Low-dose aspirin is the most beneficial prophylactic approach in this regard. Nevertheless, aspirin failure is not uncommon. The genetic, laboratory, and clinical factors associated with low-dose aspirin failure in the prevention of preeclampsia are largely unknown. The presence of a genetic variant in PAR4 receptor expressed on platelets, is associated with increased platelet function and possibly with aspirin failure.
Primary Outcome
We will compare the the allelic frequency of the PAR4 variant (rs773902) between aspirin-responders (no recurrence of preeclampsia) and aspirin non responders (recurrence of preeclampsia despite aspirin)
Conditions Studied
Interventions
- DRUG Aspirin
Study Locations (1)
New York
- Rockefeller University - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 130 participants |
| Start Date | 2023-04-13 |
| Est. Completion | 2026-11-01 |
| Phase | Early Phase 1 |
What NCT05709483 shows while recruiting
NCT05709483 is an interventional study that assigns participants to a tested intervention. The registered 130 participants enrollment target is mid-sized for trials with a published cap, below the 1,123-participant average among 48 other Preeclampsia trials with a reported enrollment target (88% lower).
The record links to 1 condition, with Preeclampsia appearing as the primary indexed condition, and to 1 intervention - of which Aspirin is the first listed.
NCT05709483 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT05709483 about?
NCT05709483 is a clinical study titled "Predictors of Aspirin Failure in Preeclampsia Prevention". Hypertensive disorders of pregnancy (including preeclampsia) are among the leading causes of pregnancy complications and maternal deaths worldwide. They also increase the risks to the babies. Numerous interventions have been suggested in order to reduce the rate of preeclampsia. Low-dose aspirin is ...
What is the current status of trial NCT05709483?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 130 participants. The study started on 2023-04-13. Estimated completion is 2026-11-01.
What conditions does trial NCT05709483 study?
This clinical trial studies the following conditions: Preeclampsia.
What interventions are being tested in trial NCT05709483?
The interventions under investigation include: Aspirin (DRUG).
Who is sponsoring clinical trial NCT05709483?
This trial is sponsored by Rockefeller University, which has 117 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05709483 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Preeclampsia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05709483's enrollment target sits among peer trials
130 26th of 48 higher than 22 of 48 other Preeclampsia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Preeclampsia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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