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RECRUITING

A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

NCT05702645 · View on ClinicalTrials.gov ↗

Study Summary

This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it is unclear of their risk for long-term effects of cancer treatment. By learning more about the factors that may contribute to chronic health conditions and long-term effects after treatment for leukemia in persons with Down syndrome, clinical practice guidelines for survivorship care can be developed to help improve their quality-of-life.

Interventions

  • PROCEDURE Biospecimen Collection
  • OTHER Survey Administration
  • OTHER Questionnaire Administration
  • OTHER Clinical Evaluation
  • OTHER Neurocognitive Assessment

Study Locations (20)

California

  • Valley Children's Hospital — Madera
  • UCSF Benioff Children's Hospital Oakland — Oakland
  • Kaiser Permanente-Oakland — Oakland
  • University of California Davis Comprehensive Cancer Center — Sacramento
  • Rady Children's Hospital - San Diego — San Diego
  • UCSF Medical Center-Mission Bay — San Francisco

Florida

  • Golisano Children's Hospital of Southwest Florida — Fort Myers
  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital — Hollywood
  • Nemours Children's Clinic-Jacksonville — Jacksonville
  • Nemours Children's Hospital — Orlando
  • Nemours Children's Clinic - Pensacola — Pensacola
  • Saint Joseph's Hospital/Children's Hospital-Tampa — Tampa

Georgia

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital — Atlanta
  • Augusta University Medical Center — Augusta

Alabama

  • Children's Hospital of Alabama — Birmingham

Arizona

  • Phoenix Childrens Hospital — Phoenix

Connecticut

  • Yale University — New Haven

Delaware

  • Alfred I duPont Hospital for Children — Wilmington

Hawaii

  • Kapiolani Medical Center for Women and Children — Honolulu

Trial Details

FieldValue
Enrollment Target 330 participants
Start Date 2023-11-30
Est. Completion 2029-06-30

Sponsor

Children's Oncology Group

318 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05702645

The ClinicalTrials.gov registry entry for NCT05702645 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 330 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Children's Oncology Group, which has 318 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Down Syndrome appearing as the primary indexed condition, and to 5 interventions — of which Biospecimen Collection is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05702645 reports 20 study locations spanning 9 distinct geographic areas — top geographies include California, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05702645 about?

NCT05702645 is a clinical study titled "A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia". This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it is unclear of their risk for long-term effects of cancer treatment. By l...

What is the current status of trial NCT05702645?

This trial is currently recruiting. The enrollment target is 330 participants. The study started on 2023-11-30. Estimated completion is 2029-06-30.

What conditions does trial NCT05702645 study?

This clinical trial studies the following conditions: Down Syndrome, Myeloid Leukemia Associated With Down Syndrome, B Acute Lymphoblastic Leukemia Associated With Down Syndrome. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05702645?

The interventions under investigation include: Biospecimen Collection (PROCEDURE), Survey Administration (OTHER), Questionnaire Administration (OTHER), Clinical Evaluation (OTHER), Neurocognitive Assessment (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05702645?

This trial is sponsored by Children's Oncology Group, which has 318 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05702645 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Connecticut, Delaware. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial