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NCT05687149 · ClinicalTrials.gov registry record
Defining the Natural History of Squamous Cell Carcinoma in Fanconi Anemia
A clinical trial of Fanconi Anemia and Inherited Bone Marrow Failure Syndrome, sponsored by National Cancer Institute (NCI).
- Recruiting
- Registry status
- 200
- Enrollment target
- 1
- Study location
NCT05687149 is a study of Fanconi Anemia and Inherited Bone Marrow Failure Syndrome that is actively recruiting participants, run by National Cancer Institute (NCI). The registered enrollment target is 200 participants, below the 323-participant average among 15 other Fanconi Anemia trials with a reported enrollment target (38% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05687149, a study of Fanconi Anemia and Inherited Bone Marrow Failure Syndrome, is actively recruiting participants, sponsored by National Cancer Institute (NCI).
- RECRUITING
- Registry status
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: Fanconi anemia (FA) is an inherited disorder. People with FA are more likely to get certain cancers, especially squamous cell carcinoma (SCC). These cancers usually appear first in the mouth, esophagus, and genital and anal areas. Early detection of SCCs may help improve survival rates for people with FA. Objective: This natural history study will regularly screen people with FA for SCC. Eligibility: People aged 12 years and older with FA or a prior cancer diagnosis. Children aged 8 to 11 years with FA may also be eligible. Design: Participants will receive a comprehensive screening for cancer or early signs of cancer. Participants will have a physical exam. They will provide blood and saliva samples. Cells will be collected by rubbing a swab on the inside of the cheeks. A skin sample may be removed from the back, buttocks, or inside of the upper arm. Participants will have pictures taken of their mouth. Any mouth sores will be mapped. Cells will be collected from the sores with a small brush. Specialists will examine the participant s ears, nose, throat, teeth, and skin. Adult participants may have a gastrointestinal exam or pelvic exam. Participants may have an endoscopy. A long tube with a camera and a light will be inserted through the mouth and down into the stomach. Participants may have a liver ultrasound. A wand will be pressed against their belly to get pictures of the organs inside the body. Participants will have screenings every year for up to 10 years. Each visit will last up to 3 days. They will have remote follow-up visits every 6 - 8 months....
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2023-03-23 |
| Est. Completion | 2035-12-31 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05687149
The ClinicalTrials.gov registry entry for NCT05687149 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 323-participant average among 15 other Fanconi Anemia trials with a reported enrollment target (38% lower). The listed sponsor is National Cancer Institute (NCI), which has 3,257 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Fanconi Anemia appearing as the primary indexed condition, and to 0 interventions.
NCT05687149 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT05687149 about?
NCT05687149 is a clinical study titled "Defining the Natural History of Squamous Cell Carcinoma in Fanconi Anemia". Background: Fanconi anemia (FA) is an inherited disorder. People with FA are more likely to get certain cancers, especially squamous cell carcinoma (SCC). These cancers usually appear first in the mouth, esophagus, and genital and anal areas. Early detection of SCCs may help improve survival rates ...
What is the current status of trial NCT05687149?
This trial is currently recruiting. The enrollment target is 200 participants. The study started on 2023-03-23. Estimated completion is 2035-12-31.
What conditions does trial NCT05687149 study?
This clinical trial studies the following conditions: Fanconi Anemia, Inherited Bone Marrow Failure Syndrome.
Who is sponsoring clinical trial NCT05687149?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05687149 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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