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NCT05685108 · ClinicalTrials.gov registry record · NA
Optimizing Ultrasound-induced Anti-inflammation in Human Subjects
A NA study of Healthy Subjects, sponsored by University of Virginia.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT05685108: Recruiting NA study of Healthy Subjects, sponsored by University of Virginia.
NCT05685108 is a NA study of Healthy Subjects that is actively recruiting participants, run by University of Virginia. The registered enrollment target is 40 participants, below the 128-participant average among 69 other Healthy Subjects trials with a reported enrollment target (69% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05685108, a NA study of Healthy Subjects, is actively recruiting participants, sponsored by University of Virginia.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a feasibility study to determine whether pulsed ultrasound stimulation targeting the splenic nerve or the cervical vagus nerve can elicit an anti-inflammatory immune response in healthy volunteers.
Primary Outcome
The primary outcome is to determine ultrasound intensities that have a biological effect on immune cells measured as a statistically significant change in the level of cytokines produced by immune cells. White blood cells will be isolated from peripheral blood and treated ex vivo with inflammatory stimuli to evaluate their capacity for cytokine production. The cytokines to be measured are (all will be measured in pg/ml): sCD40L; EGF; Eotaxin; FGF-2; FLT-3L; Fractalkine; G-CSF; GM-CSF; GRO; IFNα2
Conditions Studied
Interventions
- DEVICE Ultrasound stimulation intensity
- DEVICE Ultrasound stimulation site
Study Locations (1)
Virginia
- University of Virginia, Division of Nephrology; Center for Immunity, Inflammation & Regenerative Medicine - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2024-09-15 |
| Est. Completion | 2025-10 |
| Phase | NA |
What NCT05685108 shows while recruiting
NCT05685108 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 128-participant average among 69 other Healthy Subjects trials with a reported enrollment target (69% lower).
The record links to 1 condition, with Healthy Subjects appearing as the primary indexed condition, and to 2 interventions - of which Ultrasound stimulation intensity is the first listed.
NCT05685108 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT05685108 about?
NCT05685108 is a clinical study titled "Optimizing Ultrasound-induced Anti-inflammation in Human Subjects". This is a feasibility study to determine whether pulsed ultrasound stimulation targeting the splenic nerve or the cervical vagus nerve can elicit an anti-inflammatory immune response in healthy volunteers.
What is the current status of trial NCT05685108?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2024-09-15. Estimated completion is 2025-10.
What conditions does trial NCT05685108 study?
This clinical trial studies the following conditions: Healthy Subjects.
What interventions are being tested in trial NCT05685108?
The interventions under investigation include: Ultrasound stimulation intensity (DEVICE), Ultrasound stimulation site (DEVICE).
Who is sponsoring clinical trial NCT05685108?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05685108 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05685108's enrollment target sits among peer trials
40 30th of 69 higher than 39 of 69 other Healthy Subjects trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy Subjects trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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