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NCT05633979 · ClinicalTrials.gov registry record · Phase 1

Phase 1b Study of EZH1/2 Inhibitor Valemetostat in Combination With Trastuzumab Deruxtecan in Subjects With HER2 Low/Ultra-low/Null Metastatic Breast Cancer

A Phase 1 study of Breast Cancer, sponsored by M.D. Anderson Cancer Center.

Active
Registry status
Phase 1
Development phase
17
Enrollment target
1
Study location

NCT05633979: Active Phase 1 study of Breast Cancer, sponsored by M.D. Anderson Cancer Center.

NCT05633979 is a Phase 1 study of Breast Cancer that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 17 participants, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05633979, a Phase 1 study of Breast Cancer, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
17 participants
Enrollment target
1
Study location

Study Summary

To find a recommended dose of valemetostat that can be given in combination with trastuzumab deruxtecan to patients with low/ultra-low HER2-expressing metastatic breast cancer.

Conditions Studied

Breast Cancer

Interventions

  • DRUG Valemetostat
  • DRUG Trastuzumab deruxtecan

Study Locations (1)

Texas

  • M D Anderson Cancer Center - Houston

Trial Details

FieldValue
Enrollment Target 17 participants
Start Date 2023-02-09
Est. Completion 2032-12-31
Phase Phase 1

Sponsor

M.D. Anderson Cancer Center

2,692 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05633979

The ClinicalTrials.gov registry entry for NCT05633979 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 17 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (99% lower). The listed sponsor is M.D. Anderson Cancer Center, which has 2,692 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions - of which Valemetostat is the first listed.

NCT05633979 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT05633979 about?

NCT05633979 is a clinical study titled "Phase 1b Study of EZH1/2 Inhibitor Valemetostat in Combination With Trastuzumab Deruxtecan in Subjects With HER2 Low/Ultra-low/Null Metastatic Breast Cancer". To find a recommended dose of valemetostat that can be given in combination with trastuzumab deruxtecan to patients with low/ultra-low HER2-expressing metastatic breast cancer.

What is the current status of trial NCT05633979?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 17 participants. The study started on 2023-02-09. Estimated completion is 2032-12-31.

What conditions does trial NCT05633979 study?

This clinical trial studies the following conditions: Breast Cancer.

What interventions are being tested in trial NCT05633979?

The interventions under investigation include: Valemetostat (DRUG), Trastuzumab deruxtecan (DRUG).

Who is sponsoring clinical trial NCT05633979?

This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05633979 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Read our methodology - how this data is sourced, computed, and verified.
Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.