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ClinicalTrials.gov 9 recruiting now official registry

Surgical Site Infection clinical trials

Every US clinical trial registered for Surgical Site Infection — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

26 US clinical trials · 9 currently recruiting

The research picture

Surgical Site Infection has 26 registered US clinical trials, 9 of them open to new participants right now — about 35% of the total.

9
recruiting participants now
35%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
1
top sponsor: Durata Therapeutics Inc., an affiliate of Allergan

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 4 2,700 participants

Decolonization to Reduce After-Surgery Events of Surgical Site Infection

University of California, Irvine

NCT05586776

RECRUITING Phase 4 1,600 participants

Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery

Carilion Clinic

NCT04580472

RECRUITING Phase 3 1,100 participants

Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections

Loma Linda University

NCT06363877

RECRUITING NA 224 participants

A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™

University of North Carolina, Chapel Hill

NCT06649890

RECRUITING NA 200 participants

Irrisept Solution for Instrumented Spine Surgery

Rhode Island Hospital

NCT06439953

RECRUITING NA 100 participants

Studying How Outpatient Water affEcts Risks With Drains (SHOWER Study)

Sean Devitt

NCT04725916

RECRUITING Phase 4 84 participants

Ostomy Primary Closure With 0.1% Betaine/Polyhexanide Wound Irrigation Compared to Pursestring Closure

University of Nevada, Las Vegas

NCT06309368

RECRUITING Early Phase 1 30 participants

Zinc Oxide Versus Petrolatum Following Skin Surgery

Melissa Pugliano-Mauro

NCT03561376

RECRUITING NA 20 participants

Reducing Wound Infections Using Bioelectric Wound Dressings

AdventHealth

NCT06312267

ACTIVE NOT RECRUITING Phase 4 2,000 participants

PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)

Loreen Herwaldt

NCT05763602

ACTIVE NOT RECRUITING Phase 3 600 participants

Tobramycin Injection to Prevent Infection in Open Fractures

Massachusetts General Hospital

NCT04964947

ACTIVE NOT RECRUITING NA 343 participants

One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection

OrthoCarolina Research Institute

NCT02734134

ACTIVE NOT RECRUITING 220 participants

Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients

Boston Children's Hospital

NCT04773457

ACTIVE NOT RECRUITING NA 60 participants

Effect of Preoperative Diet on Perioperative Gut Microbiome

Stanford University

NCT05027763

COMPLETED Phase 4 1,638 participants

Pre-operative Aqueous Antiseptic Skin Solutions in Open Fractures

University of Maryland, Baltimore

NCT03385304

COMPLETED 804 participants

Reducing Perioperative S. Aureus Transmission Via OR PathTrac

Georgetown University

NCT04657185

COMPLETED Phase 4 647 participants

Multicenter Infection Surveillance Study Following Open Heart Surgery

Halyard Health

NCT00673712

COMPLETED Phase 3 573 participants

Efficacy and Safety of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections

Durata Therapeutics Inc., an affiliate of Allergan

NCT01339091

COMPLETED Phase 4 401 participants

Topical Antibiotic Prophylaxis for Eyelids

University of California, San Francis

NCT03199911

COMPLETED NA 300 participants

Air Barrier System for the Prevention of Surgical Site Infection

Nimbic Systems

NCT01610271

COMPLETED NA 298 participants

Prevena™ Incisional Negative Pressure Wound Therapy in Re-operative Colorectal Surgery

The Cleveland Clinic

NCT02509260

COMPLETED Phase 2 124 participants

Effect of Exeporfinium Chloride (XF-73) Gel on Nasal S.Aureus in Patients at Risk of Post-op Staphylococcal Infection

Destiny Pharma

NCT03915470

COMPLETED Phase 4 60 participants

SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty

St. Louis University

NCT05919888

COMPLETED NA 37 participants

The Effect of Tight Glycemic Control on Surgical Site Infection Rates in Patients Undergoing Open Heart Surgery

James A. Haley Veterans Administration Hospital

NCT01831154

COMPLETED Phase 2 36 participants

Efficacy Study to Evaluate Antimicrobial Effectiveness of ZuraPrep™ (ZX-ZP-0055)

Zurex Pharma

NCT02296645

COMPLETED Phase 2 12 participants

Topical Treatment and Prevalence of P. Acnes

University of Southern California

NCT03257202

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 3
Phase 3 3
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Surgical Site Infection Trial Landscape

ClinicalTrials.gov lists 26 US studies indexed under Surgical Site Infection, and 9 of those are currently open to recruitment — roughly 35% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Surgical Site Infection shows 11 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Surgical Site Infection is led by Durata Therapeutics Inc., an affiliate of Allergan with 1 indexed trial, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 26 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Surgical Site Infection?

PlainTrial tracks 26 US clinical trials for Surgical Site Infection, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Surgical Site Infection?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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