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Surgical Site Infection clinical trials
Every US clinical trial registered for Surgical Site Infection — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
26 US clinical trials · 9 currently recruiting
The research picture
Surgical Site Infection has 26 registered US clinical trials, 9 of them open to new participants right now — about 35% of the total.
- 9
- recruiting participants now
- 35%
- of trials open to enrollment
- 11
- in Phase 3–4 (later-stage)
- 1
- top sponsor: Durata Therapeutics Inc., an affiliate of Allergan
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Decolonization to Reduce After-Surgery Events of Surgical Site Infection
University of California, Irvine
NCT05586776
Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery
Carilion Clinic
NCT04580472
Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections
Loma Linda University
NCT06363877
A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™
University of North Carolina, Chapel Hill
NCT06649890
Irrisept Solution for Instrumented Spine Surgery
Rhode Island Hospital
NCT06439953
Studying How Outpatient Water affEcts Risks With Drains (SHOWER Study)
Sean Devitt
NCT04725916
Ostomy Primary Closure With 0.1% Betaine/Polyhexanide Wound Irrigation Compared to Pursestring Closure
University of Nevada, Las Vegas
NCT06309368
Zinc Oxide Versus Petrolatum Following Skin Surgery
Melissa Pugliano-Mauro
NCT03561376
Reducing Wound Infections Using Bioelectric Wound Dressings
AdventHealth
NCT06312267
PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)
Loreen Herwaldt
NCT05763602
Tobramycin Injection to Prevent Infection in Open Fractures
Massachusetts General Hospital
NCT04964947
One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection
OrthoCarolina Research Institute
NCT02734134
Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients
Boston Children's Hospital
NCT04773457
Effect of Preoperative Diet on Perioperative Gut Microbiome
Stanford University
NCT05027763
Pre-operative Aqueous Antiseptic Skin Solutions in Open Fractures
University of Maryland, Baltimore
NCT03385304
Reducing Perioperative S. Aureus Transmission Via OR PathTrac
Georgetown University
NCT04657185
Multicenter Infection Surveillance Study Following Open Heart Surgery
Halyard Health
NCT00673712
Efficacy and Safety of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections
Durata Therapeutics Inc., an affiliate of Allergan
NCT01339091
Topical Antibiotic Prophylaxis for Eyelids
University of California, San Francis
NCT03199911
Air Barrier System for the Prevention of Surgical Site Infection
Nimbic Systems
NCT01610271
Prevena™ Incisional Negative Pressure Wound Therapy in Re-operative Colorectal Surgery
The Cleveland Clinic
NCT02509260
Effect of Exeporfinium Chloride (XF-73) Gel on Nasal S.Aureus in Patients at Risk of Post-op Staphylococcal Infection
Destiny Pharma
NCT03915470
SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty
St. Louis University
NCT05919888
The Effect of Tight Glycemic Control on Surgical Site Infection Rates in Patients Undergoing Open Heart Surgery
James A. Haley Veterans Administration Hospital
NCT01831154
Efficacy Study to Evaluate Antimicrobial Effectiveness of ZuraPrep™ (ZX-ZP-0055)
Zurex Pharma
NCT02296645
Topical Treatment and Prevalence of P. Acnes
University of Southern California
NCT03257202
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 3 |
| Phase 3 | 3 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Surgical Site Infection Trial Landscape
ClinicalTrials.gov lists 26 US studies indexed under Surgical Site Infection, and 9 of those are currently open to recruitment — roughly 35% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Surgical Site Infection shows 11 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Surgical Site Infection is led by Durata Therapeutics Inc., an affiliate of Allergan with 1 indexed trial, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 26 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Surgical Site Infection?
PlainTrial tracks 26 US clinical trials for Surgical Site Infection, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Surgical Site Infection?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.