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A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting
NCT05452941 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to learn about how well the 20-valent pneumococcal conjugate vaccine (20vPnC) works against radiologically-confirmed community-acquired pneumonia (RAD+CAP) due to the 7 new serotypes (types of a bacteria called Streptococcus pneumoniae that cause pneumonia) included in 20vPnC vaccine. This study is seeking participants who: * are male or female ≥65 years of age. * are hospitalized with physician suspicion of community acquired pneumonia (CAP). * have pneumonia confirmed with imaging like a chest x-ray Participants will be asked to provide demographic and medical history information, and to provide a urine sample that will be used to test for pneumonia caused by specific strains of a bacteria called Streptococcus pneumoniae. We will compare the proportion of participants who have pneumonia caused by specific strains of the bacteria Streptococcus pneumoniae and were previously vaccinated with 20vPnC with the proportion of participants who have pneumonia caused by something other than vaccine type Streptococcus pneumoniae and have been vaccinated with 20vPnC. Participants will actively take part in the study for about 1-2 days. Information on participant's illness and hospitalization details will be collected through day 30 of their hospitalization through medical chart review.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Diagnostic test on urine samples
Study Locations (20)
California
- Kaiser Permanete Baldwin Park — Baldwin Park
- Kaiser Permanete Downey — Downey
- El Centro Regional Medical Center — El Centro
- Kaiser Permanente Fontana Medical Center — Fontana
- University of California San Francisco - Fresno — Fresno
- Kaiser Permanente Los Angeles Medical Center — Los Angeles
- Kaiser Permanente — Los Angeles
- Kaiser Permanente West Los Angeles Medical Center — Los Angeles
- Kaiser Permanente Vaccine Study Center — Oakland
- Kaiser Permanente Oakland Medical Center — Oakland
- Kaiser Permanente Ontario Medical — Ontario
- Southern California Permanente Medical Group (SCPMG) — Pasadena
- Kaiser Permanente Riverside Medical Center — Riverside
- Kaiser Permanente Roseville Medical Center — Roseville
- Kaiser Permanente South Sacramento Medical Center — Sacramento
- Kaiser Permanente Sacramento Medical Center — Sacramento
- Kaiser Permanente Zion Medical Center — San Diego
- Kaiser Permanente San Diego Medical Center — San Diego
- Kaiser Permanente San Jose Medical Center — San Jose
- Kaiser Permanente Santa Clara Medical Center — Santa Clara
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12,500 participants |
| Start Date | 2022-10-27 |
| Est. Completion | 2027-06-04 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05452941
The ClinicalTrials.gov registry entry for NCT05452941 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 12,500 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Pneumonia appearing as the primary indexed condition, and to 1 intervention — of which Diagnostic test on urine samples is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05452941 reports 20 study locations spanning 1 distinct geographic area — top geographies include California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05452941 about?
NCT05452941 is a clinical study titled "A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting". The purpose of this study is to learn about how well the 20-valent pneumococcal conjugate vaccine (20vPnC) works against radiologically-confirmed community-acquired pneumonia (RAD+CAP) due to the 7 new serotypes (types of a bacteria called Streptococcus pneumoniae that cause pneumonia) included in 2...
What is the current status of trial NCT05452941?
This trial is currently recruiting. The enrollment target is 12,500 participants. The study started on 2022-10-27. Estimated completion is 2027-06-04.
What conditions does trial NCT05452941 study?
This clinical trial studies the following conditions: Pneumonia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05452941?
The interventions under investigation include: Diagnostic test on urine samples (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05452941?
This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05452941 being conducted?
This trial has 20 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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