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NCT05550194 · ClinicalTrials.gov registry record · Phase 4
VZV in the Enteric Nervous System: Pathogenesis and Consequences
A Phase 4 study of Achalasia, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT05550194 is a Phase 4 study of Achalasia that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 40 participants, below the 136-participant average among 7 other Achalasia trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05550194, a Phase 4 study of Achalasia, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Varicella zoster virus (VZV) is the cause of chickenpox and shingles, but it also infects, becomes latent, and reactivates in nerve cells of the bowel to cause a gastrointestinal disorder ("enteric shingles"). The Investigators recently found that a chronic active VZV infection, a form of enteric shingles, is associated with achalasia, a severe disease in which the passage of food from esophagus to stomach is impaired. We now propose to eradicate VZV to determine whether its association with achalasia is causal, to identify the genetic basis behind VZV reactivation in the esophagus, and the relationship of mast cells to enteric shingles and abdominal pain.
Conditions Studied
Interventions
- BIOLOGICAL Shingrix
- DRUG ValACYclovir 1000 MG
Study Locations (1)
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2023-03-27 |
| Est. Completion | 2026-08 |
| Phase | Phase 4 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05550194
The ClinicalTrials.gov registry entry for NCT05550194 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 136-participant average among 7 other Achalasia trials with a reported enrollment target (71% lower). The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Achalasia appearing as the primary indexed condition, and to 2 interventions - of which Shingrix is the first listed.
NCT05550194 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.
Frequently Asked Questions
What is clinical trial NCT05550194 about?
NCT05550194 is a clinical study titled "VZV in the Enteric Nervous System: Pathogenesis and Consequences". Varicella zoster virus (VZV) is the cause of chickenpox and shingles, but it also infects, becomes latent, and reactivates in nerve cells of the bowel to cause a gastrointestinal disorder ("enteric shingles"). The Investigators recently found that a chronic active VZV infection, a form of enteric sh...
What is the current status of trial NCT05550194?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 40 participants. The study started on 2023-03-27. Estimated completion is 2026-08.
What conditions does trial NCT05550194 study?
This clinical trial studies the following conditions: Achalasia.
What interventions are being tested in trial NCT05550194?
The interventions under investigation include: Shingrix (BIOLOGICAL), ValACYclovir 1000 MG (DRUG).
Who is sponsoring clinical trial NCT05550194?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05550194 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.