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NCT05498038 · ClinicalTrials.gov registry record · NA
Exercise Reset for Concussion in a Military Environment
A NA study of Brain Concussion, sponsored by State University of New York at Buffalo.
- Recruiting
- Registry status
- NA
- Development phase
- 168
- Enrollment target
- 2
- Study locations
NCT05498038: Recruiting NA study of Brain Concussion, sponsored by State University of New York at Buffalo.
NCT05498038 is a NA study of Brain Concussion that is actively recruiting participants, run by State University of New York at Buffalo. The registered enrollment target is 168 participants, below the 288-participant average among 17 other Brain Concussion trials with a reported enrollment target (42% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05498038, a NA study of Brain Concussion, is actively recruiting participants, sponsored by State University of New York at Buffalo.
- RECRUITING
- Registry status
- NA
- Development phase
- 168 participants
- Enrollment target
- 2
- Study locations
Study Summary
Our primary objective is to show that early, personalized aerobic exercise treatment safely improves concussion recovery, speeds RTD, and reduces persistent symptoms in CSM. Our secondary objectives include demonstrating the clinical utility of our March-in-place test and determining fundamental mechanisms for the effect of exercise rehabilitation on concussion recovery. We will conduct a prospective four-year multicenter mechanistic treatment (Phase 3) RCT in CSM of personalized sub-threshold aerobic exercise added to the PRA compared with the PRA alone. Non-concussed, age-matched SM will serve as a healthy control group (HC) for comparing CSM to normal physiology and to control for the effect of time and of aerobic exercise.
Primary Outcome
PPCS is defined as recovery more than 28 days from the day of concussive injury (yes) or before 28 days (no). Recovery is defined as return to baseline symptoms, exercise tolerant and confirmation by independent medical examination.
Conditions Studied
Interventions
- BEHAVIORAL Aerobic Exercise
Study Locations (2)
North Carolina
- Fort Liberty - Fayetteville
- Camp LeJeune - Jacksonville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 168 participants |
| Start Date | 2024-08-07 |
| Est. Completion | 2026-09-30 |
| Phase | NA |
What NCT05498038 shows while recruiting
NCT05498038 is an interventional study that assigns participants to a tested intervention. The registered 168 participants enrollment target is mid-sized for trials with a published cap, below the 288-participant average among 17 other Brain Concussion trials with a reported enrollment target (42% lower).
The record links to 1 condition, with Brain Concussion appearing as the primary indexed condition, and to 1 intervention - of which Aerobic Exercise is the first listed.
NCT05498038 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT05498038 about?
NCT05498038 is a clinical study titled "Exercise Reset for Concussion in a Military Environment". Our primary objective is to show that early, personalized aerobic exercise treatment safely improves concussion recovery, speeds RTD, and reduces persistent symptoms in CSM. Our secondary objectives include demonstrating the clinical utility of our March-in-place test and determining fundamental mec...
What is the current status of trial NCT05498038?
This trial is currently recruiting. It is a NA study. The enrollment target is 168 participants. The study started on 2024-08-07. Estimated completion is 2026-09-30.
What conditions does trial NCT05498038 study?
This clinical trial studies the following conditions: Brain Concussion.
What interventions are being tested in trial NCT05498038?
The interventions under investigation include: Aerobic Exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT05498038?
This trial is sponsored by State University of New York at Buffalo, which has 243 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05498038 being conducted?
This trial has 2 study locations across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Brain Concussion
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05498038's enrollment target sits among peer trials
168 5th of 17 higher than 13 of 17 other Brain Concussion trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Brain Concussion trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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