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NCT05486949 · ClinicalTrials.gov registry record · Phase 1
Drug-drug Interactions Between AZD4205 and Itraconazole/Carbamazepine
A Phase 1 study of Healthy Subjects, sponsored by Dizal Pharmaceuticals.
- Completed
- Registry status
- Phase 1
- Development phase
- 32
- Enrollment target
- 1
- Study location
NCT05486949 is a Phase 1 study of Healthy Subjects that has completed, run by Dizal Pharmaceuticals. The registered enrollment target is 32 participants, below the 128-participant average among 69 other Healthy Subjects trials with a reported enrollment target (75% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05486949, a Phase 1 study of Healthy Subjects, has completed, sponsored by Dizal Pharmaceuticals.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 32 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a Phase 1, single-center, nonrandomized, open-label, 2-part, fixed-sequence, drug-drug interaction (DDI) study to assess the effect of multiple doses of itraconazole, a CYP3A4 enzyme inhibitor, on the single dose PK of AZD4205 in healthy adult subjects (Part A) and to assess the effect of multiple doses of carbamazepine, a CYP3A4 inducer, on the single dose PK of AZD4205 in healthy adult subjects (Part B).
Conditions Studied
Interventions
- DRUG AZD4205 and carbamazepine
- DRUG AZD4205 and itraconazole
Study Locations (1)
Kansas
- Pharmaceutical Research Associates, Inc. - Lenexa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2022-07-27 |
| Est. Completion | 2022-10-11 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05486949
The ClinicalTrials.gov registry entry for NCT05486949 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 32 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 128-participant average among 69 other Healthy Subjects trials with a reported enrollment target (75% lower). The listed sponsor is Dizal Pharmaceuticals, which has 15 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Healthy Subjects appearing as the primary indexed condition, and to 2 interventions - of which AZD4205 and carbamazepine is the first listed.
NCT05486949 reports 1 study location spanning 1 distinct geographic area - top geographies include Kansas.
Frequently Asked Questions
What is clinical trial NCT05486949 about?
NCT05486949 is a clinical study titled "Drug-drug Interactions Between AZD4205 and Itraconazole/Carbamazepine". This is a Phase 1, single-center, nonrandomized, open-label, 2-part, fixed-sequence, drug-drug interaction (DDI) study to assess the effect of multiple doses of itraconazole, a CYP3A4 enzyme inhibitor, on the single dose PK of AZD4205 in healthy adult subjects (Part A) and to assess the effect of mu...
What is the current status of trial NCT05486949?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 32 participants. The study started on 2022-07-27. Estimated completion is 2022-10-11.
What conditions does trial NCT05486949 study?
This clinical trial studies the following conditions: Healthy Subjects.
What interventions are being tested in trial NCT05486949?
The interventions under investigation include: AZD4205 and carbamazepine (DRUG), AZD4205 and itraconazole (DRUG).
Who is sponsoring clinical trial NCT05486949?
This trial is sponsored by Dizal Pharmaceuticals, which has 15 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05486949 being conducted?
This trial has 1 study location across Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.