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NCT05419726 · ClinicalTrials.gov registry record
Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.
A clinical trial of Obesity, sponsored by University of California, Los Angeles.
- Recruiting
- Registry status
- 20
- Enrollment target
- 1
- Study location
NCT05419726: Recruiting study of Obesity, sponsored by University of California, Los Angeles.
NCT05419726 is a study of Obesity that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 20 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05419726, a study of Obesity, is actively recruiting participants, sponsored by University of California, Los Angeles.
- RECRUITING
- Registry status
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
Glucagon like peptide (GLP-1) agonists, such as liraglutide, exenatide, and semaglutide, have been increasingly used as a medication to address the current twin epidemics of diabetes and obesity. Their activities include increasing insulin production by pancreatic beta cells, improving insulin sensitivity in muscles and weight loss. The mechanisms underpinning the weight loss caused by GLP-1 agonists have not yet been fully elucidated, but brown adipose tissue (BAT) appears to play an important role. We propose to assess BAT activity, using infrared thermography camera images, before individuals start weekly administration of semaglutide, at week 2-4, and week 18-20. We hypothesize that this GLP-1 agonist, semaglutide, will cause an increase in BAT activity and a corresponding increase in basal metabolic rate.
Primary Outcome
delta temperature
Conditions Studied
Interventions
- DRUG Semaglutide Injectable Product (not provided by the study)
Study Locations (1)
California
- UCLA Health - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2023-02-01 |
| Est. Completion | 2026-02-01 |
What NCT05419726 shows while recruiting
NCT05419726 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Obesity appearing as the primary indexed condition, and to 1 intervention - of which Semaglutide Injectable Product (not provided by the study) is the first listed.
NCT05419726 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05419726 about?
NCT05419726 is a clinical study titled "Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.". Glucagon like peptide (GLP-1) agonists, such as liraglutide, exenatide, and semaglutide, have been increasingly used as a medication to address the current twin epidemics of diabetes and obesity. Their activities include increasing insulin production by pancreatic beta cells, improving insulin sensi...
What is the current status of trial NCT05419726?
This trial is currently recruiting. The enrollment target is 20 participants. The study started on 2023-02-01. Estimated completion is 2026-02-01.
What conditions does trial NCT05419726 study?
This clinical trial studies the following conditions: Obesity.
What interventions are being tested in trial NCT05419726?
The interventions under investigation include: Semaglutide Injectable Product (not provided by the study) (DRUG).
Who is sponsoring clinical trial NCT05419726?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05419726 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05419726's enrollment target sits among peer trials
20 946th of 1053 higher than 80 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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