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NCT05408559 · ClinicalTrials.gov registry record · Phase 1
Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES
A Phase 1 study of Diastolic Heart Failure and Diastolic Dysfunction, sponsored by Texas Tech University Health Sciences Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 200
- Enrollment target
- 1
- Study location
NCT05408559: Recruiting Phase 1 study of Diastolic Heart Failure and Diastolic Dysfunction, sponsored by Texas Tech University Health Sciences Center.
NCT05408559 is a Phase 1 study of Diastolic Heart Failure and Diastolic Dysfunction that is actively recruiting participants, run by Texas Tech University Health Sciences Center. The registered enrollment target is 200 participants, below the 381-participant average among 7 other Diastolic Heart Failure trials with a reported enrollment target (48% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05408559, a Phase 1 study of Diastolic Heart Failure and Diastolic Dysfunction, is actively recruiting participants, sponsored by Texas Tech University Health Sciences Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
Our local IRB approved clinical studies seeking proof of principle for the hypothesis that SFN can be safely administered to humans at doses sufficient to protect age-associated cardiac dysfunctions. Beneficial effects of SFN-therapy will be assessed by Pre- and post-intervention echocardiography, and exercise endurance at 0 and 24 weeks. Peripheral blood cells from treated and control subjects will be compared for mitochondrial respiratory function, oxidative damage, pro-inflammatory cytokines, and expression of antioxidant \& anti-electrophile genes.
Conditions Studied
Interventions
- DRUG Sulforaphane
Study Locations (1)
Texas
- Texas Tech University Health Sciences Center (TTUHSC) - Lubbock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2022-07-01 |
| Est. Completion | 2026-07-30 |
| Phase | Phase 1 |
What NCT05408559 shows while recruiting
NCT05408559 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 381-participant average among 7 other Diastolic Heart Failure trials with a reported enrollment target (48% lower).
The record links to 3 conditions, with Diastolic Heart Failure appearing as the primary indexed condition, and to 1 intervention - of which Sulforaphane is the first listed.
NCT05408559 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05408559 about?
NCT05408559 is a clinical study titled "Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES". Our local IRB approved clinical studies seeking proof of principle for the hypothesis that SFN can be safely administered to humans at doses sufficient to protect age-associated cardiac dysfunctions. Beneficial effects of SFN-therapy will be assessed by Pre- and post-intervention echocardiography, a...
What is the current status of trial NCT05408559?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 200 participants. The study started on 2022-07-01. Estimated completion is 2026-07-30.
What conditions does trial NCT05408559 study?
This clinical trial studies the following conditions: Diastolic Heart Failure, Diastolic Dysfunction, Systolic Dysfunction.
What interventions are being tested in trial NCT05408559?
The interventions under investigation include: Sulforaphane (DRUG).
Who is sponsoring clinical trial NCT05408559?
This trial is sponsored by Texas Tech University Health Sciences Center, which has 76 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05408559 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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