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NCT05285371 · ClinicalTrials.gov registry record · Early Phase 1
Boluses of Ringer's in Surgical Kids (BRiSK Study)
A Early Phase 1 study, sponsored by Children's Hospital of Philadelphia.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 70
- Enrollment target
NCT05285371: Completed Early Phase 1 study, sponsored by Children's Hospital of Philadelphia.
NCT05285371 is a Early Phase 1 study that has completed, run by Children's Hospital of Philadelphia. The registered enrollment target is 70 participants, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (32% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05285371, a Early Phase 1 study, has completed, sponsored by Children's Hospital of Philadelphia.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 70 participants
- Enrollment target
Study Summary
Traditional protocols for intravenous fluid administration in children who have undergone a major abdominal or thoracic operation are based on a landmark paper published in 1957 by Holliday and Segar. The basic tenets include: (1) Continuous intravenous fluid administration; (2) Total fluid volume based on the "4:2:1" rule; (3) Use of hypotonic electrolyte solutions, most commonly 0.45% sodium chloride (NaCl) + 20 milliequivalents per liter (mEq/L) potassium chloride (KCl); and (4) Inclusion of 5% dextrose to increase the osmolarity of the infusate and to help prevent ketosis and acidemia.
Primary Outcome
Feasibility will be determined if 85% of enrolled study participants receive at least 75% of the expected study fluid in accordance to study protocol.
Interventions
- OTHER Medical Chart Review
- DIAGNOSTIC_TEST Urinalysis (UA)
- DIAGNOSTIC_TEST Complete Metabolic Panel (CMP)
- DIAGNOSTIC_TEST Glucose Stick Test (d-Stick)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2022-02-22 |
| Est. Completion | 2024-08-01 |
| Phase | Early Phase 1 |
What the finished NCT05285371 record still lists
NCT05285371 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (32% higher).
The record links to 0 conditions, and to 4 interventions - of which Medical Chart Review is the first listed.
NCT05285371 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05285371 about?
NCT05285371 is a clinical study titled "Boluses of Ringer's in Surgical Kids (BRiSK Study)". Traditional protocols for intravenous fluid administration in children who have undergone a major abdominal or thoracic operation are based on a landmark paper published in 1957 by Holliday and Segar. The basic tenets include: (1) Continuous intravenous fluid administration; (2) Total fluid volume b...
What is the current status of trial NCT05285371?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 70 participants. The study started on 2022-02-22. Estimated completion is 2024-08-01.
What interventions are being tested in trial NCT05285371?
The interventions under investigation include: Medical Chart Review (OTHER), Urinalysis (UA) (DIAGNOSTIC_TEST), Complete Metabolic Panel (CMP) (DIAGNOSTIC_TEST), Glucose Stick Test (d-Stick) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05285371?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05285371's enrollment target sits among peer trials
70 339th of 2000 higher than 1,646 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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